Fungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. In the last few years, increasing importance is attached to the health and economic problems...
Invasive fungal mycoses are a serious threat to human health, especially to immunosuppressed patients. A significant role of fungal infections in the death toll of COVID19 is also reported. Current antifungal therapies do not appear to be sufficient, therefore, identification of novel molecular targets is highly desirable. Enzymes participating in the biosynthesis pathways of essential amino acids like L-methionine (L-Met) seem...
Antifungal Effect of Penicillamine Due to the Selective Targeting of L-Homoserine O-AcetyltransferasePublication
Due to the apparent similarity of fungal and mammalian metabolic pathways, the number of established antifungal targets is low, and the identification of novel ones is highly desirable. The results of our studies, presented in this work, indicate that the fungal biosynthetic pathway of L-methionine, an amino acid essential for humans, seems to be an attractive perspective. The MET2 gene from Candida albicans encoding L-homoserine...
seen 138 times