Year 2024

• Enhanced bioactivity and mechanical properties of silicon-infused titanium oxide coatings formed by micro-arc oxidation on selective laser melted Ti13Nb13Zr alloy

  Publication

  • M. Rościszewska
  • M. Shimabukuro
  • A. Ronowska
  • A. D. Mielewczyk-Gryń
  • A. Zieliński
  • T. Hanawa

  - CERAMICS INTERNATIONAL - Year 2024

  The titanium scaffolds and surface-porous implants are manufactured by fast and cheap additive methods such as selective laser melting (SLM). The obtained irregularity and relative biological inertness of the titanium need proper surface modification. This research is aimed at forming bioactive multicomponent oxide coatings by micro-arc oxidation (MAO) at different process parameters on the selective laser-melted Ti13Zr13Nb...

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Year 2020

• Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors

  Publication

  • M. Cichorek
  • A. Ronowska
  • K. Dzierzbicka
  • M. Gensicka-Kowalewska
  • M. Deptuła
  • I. Pelikant-Malecka

  - BIOMEDICINE & PHARMACOTHERAPY - Year 2020

  The chloroacridines affect biological forms of melanoma in different ways. Amelanotic (Ab) melanoma (with inhibited melanogenesis and higher malignancy) was particularly sensitive to the action of the chloroacridines. The Ab melanoma cells died through apoptosis and through death without caspase activation. Diminished activity of TAC enzymes was noticed among Ab melanoma cells together with ATP/NAD depletion, especially in the...

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Year 2019

• Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma

  Publication

  • M. Cichorek
  • A. Ronowska
  • M. Gensicka-Kowalewska
  • M. Deptula
  • I. Pelikant-Malecka
  • K. Dzierzbicka

  - JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY - Year 2019

  PURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....

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• Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents

  Publication

  • M. Gensicka-Kowalewska
  • M. Cichorek
  • A. Ronowska
  • M. Deptuła
  • I. Klejbor
  • K. Dzierzbicka

  - Medicinal Chemistry - Year 2019

  Acridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...

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