Amira Harrous - Publications - Bridge of Knowledge

Amira Harrous

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Year 2019

Novel steroid sulfatase inhibitors based on N ‐thiophosphorylated 3‐(4‐aminophenyl)‐coumarin‐7‐O‐sulfamates
Publication
- M. Daśko
- S. Demkowicz
- K. Biernacki
- A. Harrous
- J. Rachoń
- W. Kozak
- A. Martyna
- M. Masłyk
- K. Kubiński
- A. Boguszewska‐Czubara
- DRUG DEVELOPMENT RESEARCH - Year 2019
In the present work, we described convenient methods for the synthesis ofN-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates as steroid sulfatase(STS) inhibitors. To design the structures of the potential STS inhibitors, molecularmodeling techniques were used. A computational docking method was used to deter-mine the binding modes of the synthesized inhibitors as well as to identify potentialinteractions between specified...

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