Ilona Klejbor - Publications - Bridge of Knowledge

Ilona Klejbor

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Year 2019

Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
Publication
- M. Gensicka-Kowalewska
- M. Cichorek
- A. Ronowska
- M. Deptuła
- I. Klejbor
- K. Dzierzbicka
- Medicinal Chemistry - Year 2019
Acridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...

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