Year 2022

• Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

  Publication

  • P. Sosnowski
  • P. Sass
  • P. Słonimska
  • R. Płatek
  • J. Kamińska
  • J. Baczyński-Keller
  • P. Mucha
  • G. Peszyńska-Sularz
  • A. Czupryn
  • M. Pikuła... and 5 others

  - Pharmaceuticals - Year 2022

  The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...

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Year 2020

• Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair

  Publication

  • J. Sawicka
  • M. Dzierżyńska
  • A. Wardowska
  • M. Deptuła
  • P. Rogujski
  • P. Sosnowski
  • N. Filipowicz
  • A. Mieczkowska
  • P. Sass
  • A. Pawlik... and 19 others

  - MOLECULES - Year 2020

  Regeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...

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Year 2019

• Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse

  Publication

  • P. Sass
  • P. Sosnowski
  • J. Podolak-Popinigis
  • B. Górnikiewicz
  • J. Kamińska
  • M. Deptuła
  • E. Nowicka
  • A. Wardowska
  • J. Ruczyński
  • P. Rekowski... and 12 others

  - EBioMedicine - Year 2019

  Background:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...

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• Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion

  Publication

  • J. Kamińska
  • P. Langa
  • M. Deptuła
  • J. Zieliński
  • P. Sachadyn
  • A. Wardowska
  • M. Pikuła

  - Advances in Medical Sciences - Year 2019

  PURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...

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