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The main scientific purpose of this project is to verify the hypothesis that enzymes catalyzing
reactions of L-lysine biosynthesis in Candida albicans may become new targets for
antifungal chemotherapy. Usefulness of these unique fungal enzymes as molecular bases
for new drugs discovery will be assessed by testing virulence and survival of C. albicans
mutant cells, lacking selected genes encoding enzymes of alfa-aminoadipate pathway
(AAP).
In the parallel studies, isolation, characterisation and crystallization attempts of AAP
enzymes will be carried out. Information gathered from 3D structure data obtained by X-ray
diffraction measurements and kinetic analysis will be used as basis for rational design of
inhibitors with potential use for antifungal chemotherapy and/or as fungicides.
Details
- Project's acronym:
- -
- Financial Program Name:
- Innowacyjna Gospodarka
- Organization:
- Fundacja na Rzecz Nauki Polskiej (Foundation for Polish Science)
- Agreement:
- POMOST/2010-2/4 z dnia 2011-05-17
- Realisation period:
- 2011-05-01 - 2014-07-31
- Project manager:
- dr hab. inż. Iwona Gabriel
- Realised in:
- Faculty of Chemistry
- Project's value:
- 441 100.00 PLN
- Request type:
- European Founds
- Domestic:
- Domestic project
- Verified by:
- Gdańsk University of Technology
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