Is Geotrichum candidum a new emergency pathogen? - proteome and metabolome analysis of environmental and clinical isolates
Gotrichum candidum, a fungus commonly found in soil, water, fruit, plants and dairy products, also colonizes the skin, digestive system and respiratory tract of humans. It may cause infections in humans and animals. So far, few cases of infections have been reported and they mainly concerned surface infections. However, recently, cases of both superficial and disseminated infections have begun to appear in the literature, involving people suffering from diabetes, burns, immunocompromised patients and Covid-19. Our preliminary research shows that G. candidum is widespread in the environment and shows reduced sensitivity to antimycotics. Its presence in bio-waste suggests that this fungus is also present in our homes and also comes from the food we eat. We are afraid that this species is an emergency pathogen - occurring in various infections and characterized by high resistance. The results collected in this project will allow us to provide a preliminary characterization of G. candidum. We will determine MIC values (minimum inhibitory concentrations) for basic antimycotics - which will allow us to estimate whether we have a problem with resistant isolates. We will determine whether the isolates are capable of causing infection and death of G. mellonella larvae - this will allow us to understand the dynamics of infection. Based on these studies, we will select isolates for proteome and metabolome testing.
Details
- Financial Program Name:
- MINIATURA
- Organization:
- Narodowe Centrum Nauki (NCN) (National Science Centre)
- Realisation period:
- unknown - unknown
- Project manager:
- dr inż. Martyna Mroczyńska-Szeląg
- Realised in:
- Katedra Biotechnologii i Mikrobiologii
- Request type:
- National Research Programmes
- Domestic:
- Domestic project
- Verified by:
- Gdańsk University of Technology
seen 0 times