Molecular logic lab-on-a-vesicle for intracellular diagnostics

A dysfunction of cells lining the inner walls of blood vessels, i.e. the endothelium, is the primary cause of many lifestyle related diseases. According to the WHO, those diseases accounted for 60% of all deaths worldwide in 2005. Tailor-made diagnostic tools for early and reliable identification of endothelial dysfunction are urgently needed both in fundamental research and clinical routine, respectively. The Marie Skłodowska-Curie action LOGIC LAB objects to develop and characterize innovative molecular logic gates that can be applied as advanced diagnostic tools for parallel analyte sensing in live mammalian cells. Thereby, providing a unique method to discover endothelial dysfunction and the onset of diseases much easier and earlier than so far. LOGIC LAB creates a multi-faceted and multi-sectoral research environment for the next generation of scientists in order to establish a novel type of molecular logic sensors that reliably operate in biological media – a crucial requirement for their application i.e. as rapid and easy-to-handle tools for intracellular diagnostics. With excellent cross-disciplinary scientific and complementary training provided in the network, we aim to educate highlyskilled young scientists in the fields of chemistry, physics and biology, who will significantly strengthen the international research community in the domain of molecular logic sensing. Thus, in the long term, LOGIC LAB aims to finally bridge the gap between lab bench and biological or medical practice. It is this gap, that so far prevents a wide-ranging use of existing molecular logic gates e.g. for the diagnosis of lifestyle-associated diseases.

Details

Project's acronym:

LOGIC LAB

Financial Program Name:

HORIZON 2020

Organization:

Komisja Europejska

Agreement:

813920-LogicLab z dnia 2018-08-23

Realisation period:

2018-11-01 - 2023-10-31

Research team leader:

prof. dr hab. Julien Guthmuller

Team members:

manager prof. dr hab. Julien Guthmuller

Realised in:

Department of Theoretical Physics and Quantum Information

External institutions participating in project:

SLOVAK ACADEMY OF SCIENCES (Slovakia)
UNIVERSITEIT LEIDEN (Netherlands)
DUBLIN CITY UNIVERSITY (Ireland)
FRIEDRICH-SCHILLER-UNIVERSITAT JENA (Germany)
UNIWERSYTET JAGIELLONSKI (Poland)
LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. (Germany)
SciClus GmbH & Co. KG (Germany)
MIMETAS BV (Netherlands)

Project's value:

3 538 684.00 EUR

Request type:

International Research Programmes

Domestic:

International project

Verified by:

Gdańsk University of Technology

Papers associated with that project

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total: 3

Year 2023

A BODIPY‐Based Molecular Rotor in Giant Unilamellar Vesicles: A Case Study by Polarization‐Resolved Time‐Resolved Emission and Transient Absorption Spectroscopy
Publication
- K. K. Jha
- A. Prabhakaran
- L. Spantzel
- R. C. Sia
- I. Pérez
- R. A. Arellano-Reyes
- A. Elmanova
- A. Dasgupta
- C. Eggeling
- M. Börsch... and 4 others
- ChemPhotoChem - Year 2023
BODIPY and BODIPY-derived systems are widely applied as fluorophores and as probes for viscosity detection in solvents and biological media. Their orientational and rotational dynamics in biological media are thus of vital mechanistic importance and extensively investigated. In this contribution, polarization-resolved confocal microscopy is used to determine the orientation of an amphiphilic BODIPY-cholesterol derivative in homogeneous...

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BODIPY‐Perylene Charge Transfer Compounds; Sensitizers for Triplet‐Triplet Annihilation Up‐conversion
Publication
- R. A. Arellano-Reyes
- A. Prabhakaran
- R. C. Sia
- J. Guthmuller
- K. K. Jha
- T. Yang
- B. Dietzek‐Ivanšić
- V. McKee
- T. E. Keyes
- CHEMISTRY-A EUROPEAN JOURNAL - Year 2023
BODIPY heterochromophores, asymmetrically substituted with perylene and/or iodine at the 2 and 6 positions were prepared and investigated as sensitizers for triplet-triplet annihilation up conversion (TTA-UC). Single-crystal X-ray crystallographic analyses show that the torsion angle between BODIPY and perylene units lie between 73.54 and 74.51, though they are not orthogonal. Both compounds show intense, charge transfer absorption...

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Triplet Formation and Triplet‐Triplet Annihilation Upconversion in Iodine Substituted Non‐Orthogonal BODIPY‐Perylene Dyads
Publication
- K. Kumar Jha
- A. Prabhakaran
- R. C. Sia
- R. A. Arellano-Reyes
- N. Kumar Sarangi
- T. Yang
- K. Kumar
- S. Kupfer
- J. Guthmuller
- T. E. Keyes
- B. Dietzek-Ivanšić
- ChemPhotoChem - Year 2023
BODIPY-perylene dyads have emerged as useful metal free sensitizers for triplet-triplet annihilation upconversion (TTAUC), these dyads are capable of efficient triplet generation via spinorbit charge transfer intersystem crossing (SOCT-ISC). This important route to triplet formation requires dyads in which two moieties are oriented perpendicular to each other. In this contribution, we give a deeper insight on the behavior of recently...

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