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A subset of two adherence systems, acute pro-inflammatory pap genes and invasion coding dra, fim, or sfa, increases the risk of Escherichia coli translocation to the bloodstream
Abstract
An analysis of the phylogenetic distribution and virulence genes of Escherichia coli isolates which predispose this bacteria to translocate from the urinary tract to the bloodstream is presented. One-dimensional analysis indicated that the occurrence of P fimbriae and α-hemolysin coding genes is more frequent among the E. coli which cause bacteremia. However, a two-dimensional analysis revealed that a combination of genes coding two adherence factors, namely, P + Dr, P + S, S + Dr, S + fim, and hemolysin + one adherence factor, were associated with bacteremia and, therefore, with the risk of translocation to the vascular system. The frequent and previously unrecognized co-existence of pro-inflammatory P fimbriae with the invasion promoting Dr adhesin in the same E. coli isolate may represent high-risk and potentially lethal pathogens.
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Authors (7)
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Alfred Samet
- Gdański Uniwersytet Medyczny Laboratorium Mikrobiologii Klinicznej
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Anna Śledzińska
- Gdański Uniwersytet Medyczny Laboratorium Mikrobiologii Klinicznej
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Bogdan Nowicki
- Meharry Medical College, Nashville Department of Obstetrics and Gynecology and Department of Microbiology and Immunology
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Stella Nowicki
- Meharry Medical College, Nashville Department of Obstetrics and Gynecology and Department of Microbiology and Immunology
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1007/s10096-013-1913-x
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
no. 32,
edition 12,
pages 1579 - 1582,
ISSN: 0934-9723 - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Szemiako K., Krawczyk B., Samet A., Śledzińska A., Nowicki B., Nowicki S., Kur J.: A subset of two adherence systems, acute pro-inflammatory pap genes and invasion coding dra, fim, or sfa, increases the risk of Escherichia coli translocation to the bloodstream// EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. -Vol. 32, iss. 12 (2013), s.1579-1582
- DOI:
- Digital Object Identifier (open in new tab) 10.1007/s10096-013-1913-x
- Verified by:
- Gdańsk University of Technology
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