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Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis
Abstract
Lubrication of articular cartilage is a complex multiscale phenomenon in synovial joint organ systems. In these systems, synovial fluid properties result from synergistic interactions between a variety of molecular constituent. Two molecular classes in particular are of importance in understanding lubrication mechanisms: hyaluronic acid and phospholipids. The purpose of this study is to evaluate interactions between hyaluronic acid and phospholipids at various functionality levels during normal and pathological synovial fluid conditions. Molecular dynamic simulations of hyaluronic acid and phospholipids complexes were performed with the concentration of hyaluronic acid set at a constant value for two organizational forms, extended (normal) and coiled (pathologic). The results demonstrated that phospholipids affect the crosslinking mechanisms of hyaluronic acid significantly and the influence is higher during pathological conditions. During normal conditions, hyaluronic acid and phospholipid interactions seem to have no competing mechanism to that of the interaction between hyaluronic acid to hyaluronic acid. On the other hand, the structures formed under pathologic conditions were highly affected by phospholipid concentration.
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Authors (7)
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Piotr Bełdowski
- UTP University of Science and Technology
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Tomasz Andrysiak
- UTP University of Science and Technology
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Wayne Auge
- NuOrtho Surgical, Inc.
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Damian Ledziński
- UTP University of Science and Technology
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Tristan DeLeon
- College of Mathematics, Natural Sciences and Technology, Delaware State University
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Adam Gadomski
- UTP University of Science and Technology
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
no. 18,
pages 1 - 16,
ISSN: 1661-6596 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Bełdowski P., Weber P., Andrysiak T., Auge W., Ledziński D., Deleon T., Gadomski A.: Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. -Vol. 18, nr. 12 (2017), s.1-16
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms18122779
- Verified by:
- Gdańsk University of Technology
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