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Combined analysis of whole human blood parameters by Raman spectroscopy and spectral-domain low-coherence interferometry
Abstract
In this article the simultaneous investigation of blood parameters by complementary optical methods, Raman spectroscopy and spectral-domain low-coherence interferometry, is presented. Thus, the mutual relationship between chemical and physical properties may be investigated, because low-coherence interferometry measures optical properties of the investigated object, while Raman spectroscopy gives information about its molecular composition. A series of in-vitro measurements were carried out to assess sufficient accuracy for monitoring of blood parameters. A vast number of blood samples with various hematological parameters, collected from different donors, were measured in order to achieve a statistical significance of results and validation of the methods. Preliminary results indicate the benefits in combination of presented complementary methods and form the basis for development of a multimodal system for rapid and accurate optical determination of selected parameters in whole human blood. Future development of optical systems and multivariate calibration models are planned to extend the number of detected blood parameters and provide a robust quantitative multi-component analysis.
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Keywords
Details
- Category:
- Conference activity
- Type:
- materiały konferencyjne indeksowane w Web of Science
- Title of issue:
- Conference on Clinical and Biomedical Spectroscopy and Imaging IV held at the European Conferences on Biomedical Optics strony 1 - 5
- ISSN:
- 0277-786X
- Language:
- English
- Publication year:
- 2015
- Bibliographic description:
- Gnyba M., Wróbel M., Karpienko K., Majchrowicz D., Jędrzejewska-Szczerska M..: Combined analysis of whole human blood parameters by Raman spectroscopy and spectral-domain low-coherence interferometry, W: Conference on Clinical and Biomedical Spectroscopy and Imaging IV held at the European Conferences on Biomedical Optics, 2015, SPIE-INT SOC OPTICAL ENGINEERING,.
- DOI:
- Digital Object Identifier (open in new tab) 10.1117/12.2183645
- Verified by:
- Gdańsk University of Technology
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