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Abstract
Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in developing biomedical chitosan for DDSs. Methods deployed for modifying the properties and performance of chitosan hydrogels, via their composite production (semi- and full-interpenetrating networks), are also cogitated here. In addition, recent advances in the fabrication of advanced chitosan hydrogels for drug delivery applications such as oral drug delivery, transdermal drug delivery, and cancer therapy are discussed. Lastly, thoughts on what is needed for the chitosan field to continue to grow is also debated in this comprehensive review article.
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Authors (14)
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Mostafa Saeedi
-
Omid Vahidi
-
Mohammad Reza Moghbeli
-
Sepideh Ahmadi
-
Mohsen Asadnia
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Omid Akhavan
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Farzad Seidi
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Mohammad Rabiee
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Thomas J. Webster
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Rajender S. Varma
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Esmaeel Sharifi
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Ali Zarrabi
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Navid Rabiee
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Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
JOURNAL OF CONTROLLED RELEASE
no. 350,
pages 175 - 192,
ISSN: 0168-3659 - Language:
- English
- Publication year:
- 2022
- Bibliographic description:
- Saeedi M., Vahidi O., Moghbeli M. R., Ahmadi S., Asadnia M., Akhavan O., Seidi F., Rabiee M., Saeb M., Webster T. J., Varma R. S., Sharifi E., Zarrabi A., Rabiee N.: Customizing nano-chitosan for sustainable drug delivery// JOURNAL OF CONTROLLED RELEASE -Vol. 350, (2022), s.175-192
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.jconrel.2022.07.038
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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