Abstract
Prion diseases are characterized by the conversion of prion proteins from a PrPC fold into a disease-causing PrPSC form that is self-replicating. A possible agent to trigger this conversion is polyadenosine RNA, but both mechanism and pathways of the conversion are poorly understood. Using coarse-grained molecular dynamic simulations we study the time evolution of PrPC over 600 μs. We find that both the D178N mutation and interacting with polyadenosine RNA reduce the helicity of the protein and encourage formation of segments with strand-like motifs. We conjecture that these transient β-strands nucleate the conversion of the protein to the scrapie conformation PrPSC.
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acs.jpcb.2c04614
- License
- Copyright (2022 American Chemical Society)
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
JOURNAL OF PHYSICAL CHEMISTRY B
no. 126,
pages 6221 - 6230,
ISSN: 1520-6106 - Language:
- English
- Publication year:
- 2022
- Bibliographic description:
- Lubecka E., Hansmann U. H. E.: Early Stages of RNA-Mediated Conversion of Human Prions// JOURNAL OF PHYSICAL CHEMISTRY B -Vol. 126,iss. 33 (2022), s.6221-6230
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acs.jpcb.2c04614
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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