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Abstract
Background: Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. Objectives: The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. Study design: The study included 132 lung cancer patients and 396 controls from northern Poland, matched by sex, age and smoking status. The median cigarette pack-years of smoking among both cases and controls was 30.0. Serum, red blood cell (RBC) folates and serum homocysteine concentrations were measured. The genotypes in selected polymorphic sites of the MTHFR, CBS, SHMT1, MTHFD1, MTRR, MTR, TYMS DHFR, TCN2, and SLC19A1 genes were determined. All study participants underwent scanning with low-dose computed tomography. Results: Serum folate concentrations above the median (> 17.5 nmol/l among the healthy controls) were associated with an increased lung cancer risk (odds ratio [OR], 1.54, 95% confidence intervals [CI], 1.04-2.29, P= 0.031). An analogous trend was observed when the population was analysed after subdivision according to RBC folate concentrations, that is, above a value of 506.5 nmol/l (OR, 1.53; 95% CI, 0.95-2.47; P=0.084). Additionally, in a subset of women, an increased risk of lung cancer development was associated with the SLC19A1 c.80AA genotype (c.80AA versus GG OR, 3.14; 95% CI, 1.32-7.46; P= P=0.010). Conclusion: These results suggest that, in the population consisting of heavy smokers, high folate levels add to the cancerogenic effect of smoking.
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Authors (8)
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Joanna Borzyszkowska
- Gdański Uniwersytet Medyczny / Wydział Lekarski Katedra i Zakład Biologii i Genetyki Medycznej
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Alicja Janowicz
- Gdański Uniwersytet Medyczny / Wydział Lekarski Katedra i Klinika Chirurgii Klatki Piersiowej
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Rafał Dziadziuszko
- Gdański Uniwersytet Medyczny / Wydział Lekarski Katedra i Klinika Onkologii i Radioterapii
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Jacek Jassem
- Gdański Uniwersytet Medyczny / Wydział Lekarski Katedra i Klinika Onkologii i Radioterapii
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Witold Rzyman
- Gdański Uniwersytet Medyczny / Wydział Lekarski Katedra i Klinika Chirurgii Klatki Piersiowej
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Janusz Limon Prof. dr hab.
- Gdański Uniwersytet Medyczny / Wydział Lekarski Katedra i Zakład Biologii i Genetyki Medycznej
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1371/journal.pone.0214462
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
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PLOS ONE
no. 14,
ISSN: 1932-6203 - Language:
- English
- Publication year:
- 2019
- Bibliographic description:
- Stanisławska-Sachadyn A., Borzyszkowska J., Krzemiński M., Janowicz A., Dziadziuszko R., Jassem J., Rzyman W., Limon J.: Folate/homocysteine metabolism and lung cancer risk among smokers// PLOS ONE. -Vol. 14, iss. 4 (2019), s.e0214462-
- DOI:
- Digital Object Identifier (open in new tab) 10.1371/journal.pone.0214462
- Verified by:
- Gdańsk University of Technology
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