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Abstract
The present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1-/-) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards HT29 and MCF7 cells started from 6 h of treatment at the concentration of 0.5 mg/mL DW. The lowest concentration (0.125 mg/mL DW) of the investigated extract expressed cytotoxicity after 72 hours following cancer cell treatment. In contrast to the cancer cells, in the case of the tested non-cancer cells, cytotoxic effect was not observed at the applied concentrations. The extract sub-cytotoxic concentration, in this case, was reported to be the 1 mg/mL DW. Further investigations are needed to confirm the selective cytotoxicity and possible action mechanisms of the leaf extract of R. nigrum.
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Authors (7)
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Mikayel Ginovyan PhD
-
Pierre Andreoletti
-
Mustapha Cherkaoui-malki
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Naira Sahakyan
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3934/biophy.2022024
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
AIMS Biophysics
no. 9,
pages 282 - 293,
ISSN: 2377-9098 - Language:
- English
- Publication year:
- 2022
- Bibliographic description:
- Ginovyan M., Bartoszek-Pączkowska A., Koss-Mikołajczyk I., Kusznierewicz B., Andreoletti P., Cherkaoui-malki M., Sahakyan N.: Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract// AIMS Biophysics -Vol. 9,iss. 4 (2022), s.282-293
- DOI:
- Digital Object Identifier (open in new tab) 10.3934/biophy.2022024
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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