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Intramolecular transformation of an antifungal antibiotic nystatin A1 into its isomer, iso-nystatin A1 - structural and molecular modeling studies
Abstract
Nystatin A1, a polyene macrolide antifungal antibiotic, in a slightly basic or acidic solution undergoes an intramolecular transformation, yielding a structural isomer, the translactonization product, iso-nystatin A1 with lactone ring diminished by two carbon atoms. Structural evidence is provided by advanced NMR and Mass Spectrometry (MS) studies. Molecular dynamics simulations and quantum mechanics calculations gave the insight into the course and mechanism of the transformation and its effect on the conformation of the subject molecule.
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
MAGNETIC RESONANCE IN CHEMISTRY
no. 54,
edition 12,
pages 953 - 961,
ISSN: 0749-1581 - Language:
- English
- Publication year:
- 2016
- Bibliographic description:
- Szwarc K., Płosiński M., Czerniejewska K., Laskowski T., Leniak A., Czub J., Kubica P., Sowiński P., Pawlak J., Borowski E.: Intramolecular transformation of an antifungal antibiotic nystatin A1 into its isomer, iso-nystatin A1 - structural and molecular modeling studies// MAGNETIC RESONANCE IN CHEMISTRY. -Vol. 54, iss. 12 (2016), s.953-961
- DOI:
- Digital Object Identifier (open in new tab) 10.1002/mrc.4478
- Verified by:
- Gdańsk University of Technology
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