Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties - Publication - Bridge of Knowledge

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Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties

Abstract

Pyrazine and its derivatives are a large group of compounds that exhibit broad biological activity, the changes of which can be easily detected by a substituent effect or a change in the functional group. The present studies combined theoretical research with the density functional theory (DFT) approach (B3LYP/6-311+G**) and experimental (potentiometric and spectrophotometric) analysis for a thorough understanding of the structure of chlorohydrazinopyrazine, its physicochemical and cytotoxic properties, and the site and nature of interaction with DNA. The obtained results indicated that 2-chloro-3-hydrazinopyrazine (2Cl3HP) displayed the highest affinity to DNA. Cytotoxicity studies revealed that the compound did not exhibit toxicity toward human dermal keratinocytes, which supported the potential application of 2Cl3HP in clinical use. The study also attempted to establish the possible equilibria occurring in the aqueous solution and, using both theoretical and experimental methods, clearly showed the hydrophilic nature of the compound. The experimental and theoretical results of the study confirmed the quality of the compound, as well as the appropriateness of the selected set of methods for similar research.

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DOI:
Digital Object Identifier (open in new tab) 10.3390/molecules27123704
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Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
MOLECULES no. 27,
ISSN: 1420-3049
Language:
English
Publication year:
2022
Bibliographic description:
Mech-Warda P., Artur G., Kawiak A., Maciejewska N., Olszewski M., Makowski M., Chylewska A.: Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties// MOLECULES -Vol. 27,iss. 12 (2022), s.3704-
DOI:
Digital Object Identifier (open in new tab) 10.3390/molecules27123704
Verified by:
Gdańsk University of Technology

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