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Abstract
Accurate and fast detection of viruses is crucial for controlling outbreaks of many diseases; therefore, to date, numerous sensing systems for their detection have been studied. On top of the performance of these sensing systems, the availability of biorecognition elements specific to especially the new etiological agents is an additional fundamental challenge. Therefore, besides high sensitivity and selectivity, such advantages as the size of the sensor and possibly low volume of analyzed samples are also important, especially at the stage of evaluating the receptor-target interactions in the case of new etiological agents when typically, only tiny amounts of the receptor are available for testing. This work introduces a real-time, highly miniaturized sensing solution based on microcavity in-line Mach–Zehnder interferometer (μIMZI) induced in optical fiber for SARS-CoV-2 virus-like particles detection. The assay is designed to detect conserved regions of the SARS-CoV-2 viral particles in a sample with a volume as small as hundreds of picoliters, reaching the detection limit at the single ng per mL level.
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Authors (13)
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Tomasz Gabler mgr inż
- Politechnika Warszawska
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Marcin Koba
- Politechnika Warszawska
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Mirosława Panasiuk
- Instytut Biotechnologii i Medycyny Molekularnej
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Yanina Dashkevich
- Instytut Biotechnologii i Medycyny Molekularnej
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Tomasz Łęga
- Instytut Biotechnologii i Medycyny Molekularnej
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Agnieszka Dąbrowska
- Uniwersytet Jagielloński
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Antonina Naskalska dr
- Uniwersytet Jagielloński
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Sabina Żołędowska dr
- Instytut Biotechnologii i Medycyny Molekularnej
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Dawid Nidzworski dr
- Instytut Biotechnologii i Medycyny Molekularnej
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Krzysztof Pyrć Prof.
- Uniwersytet Jagielloński
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Beata Gromadzka
- Instytut Biotechnologii i Medycyny Molekularnej
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Mateusz Śmietana
- Politechnika Warszawska
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1038/s41598-023-28790-y
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Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Scientific Reports
no. 13,
ISSN: 2045-2322 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Janik M., Gabler T., Koba M., Panasiuk M., Dashkevich Y., Łęga T., Dąbrowska A., Naskalska A., Żołędowska S., Nidzworski D., Pyrć K., Gromadzka B., Śmietana M.: Low-volume label-free SARS-CoV-2 detection with the microcavity-based optical fiber sensor// Scientific Reports -,iss. 13 (2023),
- DOI:
- Digital Object Identifier (open in new tab) 10.1038/s41598-023-28790-y
- Sources of funding:
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- Publikacja finansowana ze środków Politechniki Warszawskiej
- Verified by:
- Gdańsk University of Technology
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