Modeling of Cardiac Component of Subarachnoid Space Changes in Apnoea Resulting as a Function of Blood Pressure and Blood Flow Parameters - Two Mechanizm of Regulation
Abstract
Experiments were performed in a group of 19 healthy, non-smoking volunteers. The experiment consisted of three apnoeas, sequentially: 30 s apnoea, 60 s apnoea and maximal, that could be done, apnoea. The breath-hold was separated for 5 minutes rest. The following parameters were measured and obtained for further analysis: blood parameters, artery diameter of the internal carotid artery, end-tidal CO2 in expired air, the cardiac (from 0.5 to 5.0 Hz) and slow (< 0.5 Hz) components of subarachnoid space width signal. As a result of the experiment, we observed two different reactions, using the same experimental procedure. It seemed to indicate two different operating modes and two separate models. As a consequence, there are two subsets of slow subarachnoid space width responses to breath-hold in humans. A positive subarachnoid space width changes (slow) component depends on changes in heart rate, pulsatility index and cerebral blood flow velocity. A negative subarachnoid space width cha nges component is driven by heart rate changes and pulsatility index changes. The different heart-generated arterial pulsation response to experimental breath-hold provides new insights into our understanding of the complex mechanisms governing the adaptation to apnoea in humans. We propose a mathematical methodology that can be used in further clinical research.
Citations
-
0
CrossRef
-
0
Web of Science
-
0
Scopus
Authors (4)
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Conference activity
- Type:
- materiały konferencyjne indeksowane w Web of Science
- Title of issue:
- Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS strony 140 - 147
- Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Mazur K., Kalicka R., Frydrychowski A. F., Winklewski P. J..: Modeling of Cardiac Component of Subarachnoid Space Changes in Apnoea Resulting as a Function of Blood Pressure and Blood Flow Parameters - Two Mechanizm of Regulation, W: Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, 2017, ,.
- DOI:
- Digital Object Identifier (open in new tab) 10.5220/0006139901400147
- Verified by:
- Gdańsk University of Technology
seen 76 times
Recommended for you
Pial artery and subarachnoid width response to apnoea in normal humans
- M. Wszędybył-Winklewska,
- J. Wolf,
- E. Świerblewska
- + 8 authors
Effect of Maximal Breath Hold Apnea on Pial Artery Pulsation and Subarachnoid Width in Human
- P. J. Winklewski,
- J. Wolf,
- E. Świerblewska
- + 7 authors
Effect of Maximal Apnoea Easy-Going and Struggle Phases on Subarachnoid Width and Pial Artery Pulsation in Elite Breath-Hold Divers
- P. Winklewski,
- O. Barak,
- D. Madden
- + 7 authors