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Abstract
Critical Assessment of Structure Prediction (CASP) is an organization aimed at advancing the state of the art in computing protein structure from sequence. In the spring of 2020, CASP launched a community project to compute the structures of the most structurally challenging proteins coded for in the SARS-CoV-2 genome. Forty-seven research groups submitted over 3000 three-dimensional models and 700 sets of accuracy estimates on 10 proteins. The resulting models were released to the public. CASP community members also worked together to provide estimates of local and global accuracy and identify structure-based domain boundaries for some proteins. Subsequently, two of these structures (ORF3a and ORF8) have been solved experimentally, allowing assessment of both model quality and the accuracy estimates. Models from the AlphaFold2 group were found to have good agreement with the experimental structures, with main chain GDT_TS accuracy scores ranging from 63 (a correct topology) to 87 (competitive with experiment).
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Authors (89)
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Andriy Kryshtafovych
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John Moult
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Wendy M. Billings
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Dennis Della Corte
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Krzysztof Fidelis
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Sohee Kwon
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Kliment Olechnovič
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Chaok Seok
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Česlovas Venclovas
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Jonghun Won
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Alphafold Team
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Badri Adhikari
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Recep Adiyaman
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Joaquim Aguirre-plans
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Ivan Anishchenko
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Minkyung Baek
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David Baker
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Frederico Baldassarre
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Jacob Barger
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Sutanu Bhattacharya
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Debswapna Bhattacharya
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Mor Bitton
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Renzhi Cao
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Jianlin Cheng
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Charles Christoffer
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Cezary Czaplewski Dr hab.
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Zongyang Du
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Arne Elofsson
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Eshel Faraggi
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Michael Feig
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Narcis Fernandez-fuentes
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Nick Grishin
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Sergei Grudinin
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Zhiye Guo
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Yuya Hanazono
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Demis Hassabis
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Bryce Hedelius
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Lim Heo
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Naozumi Hiranuma
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Cassandra Hunt
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Ilia Igashov
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Takashi Ishida
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Robert L. Jernigan
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David Jones
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John Jumper
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Maria Kadukova
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Shaun Kandathil
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Chen Keasar
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Daisuke Kihara
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Lisa Kinch
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Yasuomi Kiyota
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Andrzej Kloczkowski
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Pushmeet Kohli
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Mateusz Kogut
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Elodie Laine
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Cade Lilley
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Jian Liu
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Adam Liwo
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Arup Mondal
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Connor J. Morris
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Liam Mcguffin
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Alexis Molina
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Tsukasa Nakamura
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Baldo Oliva
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Alberto Perez
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Gabriele Pozzati
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Daipayan Sarkar
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Rin Sato
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Torsten Schwede
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Bikash Shrestha
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Tomer Sidi
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Gabriel Studer
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Md Hossain Shuvo
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Mayuko Takeda-shitaka
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Yuma Takei
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Genki Terashi
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Kentaro Tomii
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Yuko Tsuchiya
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Kathryn Tunyasuvunakool
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Bjorn Wallner
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Tianqi Wu
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Jinbo Xu
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Yu Yamamori
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Jianyi Yang
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Lisha Ye
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Chengxin Zhang
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Yang Zhang
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Wei Zheng
Cite as
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Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
no. 89,
pages 1987 - 1996,
ISSN: 0887-3585 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Kryshtafovych A., Moult J., Billings W. M., Della Corte D., Fidelis K., Kwon S., Olechnovič K., Seok C., Venclovas Č., Won J., Team A., Adhikari B., Adiyaman R., Aguirre-Plans J., Anishchenko I., Baek M., Baker D., Baldassarre F., Barger J., Bhattacharya S., Bhattacharya D., Bitton M., Cao R., Cheng J., Christoffer C., Czaplewski C., Du Z., Elofsson A., Faraggi E., Feig M., Fernandez-Fuentes N., Grishin N., Grudinin S., Guo Z., Hanazono Y., Hassabis D., Hedelius B., Heo L., Hiranuma N., Hunt C., Igashov I., Ishida T., Jernigan R. L., Jones D., Jumper J., Kadukova M., Kandathil S., Keasar C., Kihara D., Kinch L., Kiyota Y., Kloczkowski A., Kohli P., Kogut M., Laine E., Lilley C., Liu J., Liwo A., Lubecka E., Mondal A., Morris C. J., Mcguffin L., Molina A., Nakamura T., Oliva B., Perez A., Pozzati G., Sarkar D., Sato R., Schwede T., Shrestha B., Sidi T., Studer G., Shuvo M. H., Takeda-Shitaka M., Takei Y., Terashi G., Tomii K., Tsuchiya Y., Tunyasuvunakool K., Wallner B., Wu T., Xu J., Yamamori Y., Yang J., Ye L., Zhang C., Zhang Y., Zheng W.: Modeling SARS‐CoV‐2 proteins in the CASP‐commons experiment// PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS -Vol. 89,iss. 12 (2021), s.1987-1996
- DOI:
- Digital Object Identifier (open in new tab) 10.1002/prot.26231
- Verified by:
- Gdańsk University of Technology
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