NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up - Publication - Bridge of Knowledge

Your account

login

Search

NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up

Abstract

The CYBA gene encodes the regulatory subunit of NADPH oxidase, which maintains the redox state within cells and in the blood vessels. That led us to investigate the course of coronary artery disease (CAD) with regards to CYBA polymorphisms. Thus, we recruited 1197 subjects with coronary atherosclerosis and observed them during 7-year follow-up. Three CYBA polymorphisms: c.214C>T (rs4673), c.-932G>A (rs9932581), and c.*24G>A (1049255) were studied for an association with death, major adverse cardiovascular events (MACE) and an elective percutaneous coronary intervention or coronary artery bypass grafting (PCI/CABG). We found an association between the CYBA c.214C>T polymorphism and two end points: death and PCI/CABG. CYBA c.214TT genotype was associated with a lower risk of death than C allele (9.5% vs. 21%, p < 0.05) and a higher risk of PCI/CABG than C allele (69.3% vs. 51.7%, p < 0.01). This suggests that the CYBA c.214TT genotype may be a protective factor against death OR = 0.47 (95%CI 0.28–0.82; p < 0.01), while also being a risk factor for an elective PCI/CABG OR = 2.36 (95%CI 1.15–4.82; p < 0.05). Thus, we hypothesize that among patients with coronary atherosclerosis, the CYBA c.214TT genotype contributes to atherosclerotic plaque stability by altering the course of CAD towards chronic coronary syndrome, thereby lowering the incidence of fatal CAD-related events.

Citations

  • 9

    CrossRef

  • 0

    Web of Science

  • 8

    Scopus

Authors (10)

Cite as

Full text

download paper
downloaded 50 times
Publication version
Accepted or Published Version
DOI:
Digital Object Identifier (open in new tab) 10.3390/jcm9051475
License
Creative Commons: CC-BY open in new tab

Keywords

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
Journal of Clinical Medicine no. 9,
ISSN: 2077-0383
Language:
English
Publication year:
2020
Bibliographic description:
Racis M., Sobiczewski W., Stanisławska-Sachadyn A., Wirtwein M., Bluj E., Nedoszytko M., Borzyszkowska J., Limon J., Rynkiewicz A., Gruchała M.: NADPH Oxidase Gene Polymorphism is Associated with Mortality and Cardiovascular Events in 7-Year Follow-Up// Journal of Clinical Medicine -Vol. 9,iss. 5 (2020), s.1475-
DOI:
Digital Object Identifier (open in new tab) 10.3390/jcm9051475
Verified by:
Gdańsk University of Technology

seen 144 times

Recommended for you

Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis

2020

Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding

  • Z. Waldman,
  • L. Camarillo-Rodriguez,
  • I. Chervenova
  • + 24 authors
2018

Catheter-induced coronary artery and aortic dissections. A study of the mechanisms, risk factors, and propagation causes

2024

Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis

  • A. Mickiewicz,
  • M. Futema,
  • A. Ćwiklinska
  • + 9 authors
2020
Meta Tags