Patomechanizm zakażeń dróg moczowych wywoływanych przez uropatogenne szczepy E. coli - Publication - Bridge of Knowledge

Search

Patomechanizm zakażeń dróg moczowych wywoływanych przez uropatogenne szczepy E. coli

Abstract

Zakażenia układu moczowego (ZUM) to jedne z najczęstszych i najbardziej powszechnych infekcji bakteryjnych, dotykających każdego roku nawet 150 milionów ludzi na świecie. Problem z tego typu infekcjami wynika z przewlekłości choroby, nawrotów i wzrastającej lekooporności powodujących je patogenów. Uropatogenne szczepy E. coli (UPEC) są głównym czynnikiem przyczynowym ZUM. Bakterie tej grupy zawierają wiele czynników adhezyjnych umiejscowionych na powierzchni ich komórek, które odpowiadają za wstępny etap bakteryjnej adherencji i kolonizację dróg moczowych. Spośród UPEC najbardziej rozpowszechnione są monoadhezyjne pile typu 1 i P oraz poliadhezyny rodziny Dr, których biogeneza odbywa się według zakonserwowanego systemu sekrecji typu „chaperone-usher” (CUP). Poza czynnikami urowirulencji, szczepy UPEC wykształciły wiele mechanizmów istotnych w patogenezie ZUM i umożliwiających im przetrwanie w środowisku dróg moczowych (adhezja, inwazja, formowanie wewnątrzkomórkowych agregatów i wyciszonych rezerwuarów bakteryjnych, filamentacja bakterii, oporność na antybiotyki). Powszechnie stosowana terapia antybiotykowa wydaje się bardzo skuteczna w kontrolowaniu i terapii ZUM, jednak narastająca wielolekooporność szczepów bakteryjnych, jak i bardzo częste nawroty zakażeń, są podstawą rozwoju alternatywnych form terapeutycznych i strategii prewencyjnych.

Citations

  • 2

    CrossRef

  • 0

    Web of Science

  • 2

    Scopus

Cite as

Full text

download paper
downloaded 1575 times
Publication version
Accepted or Published Version
License
Creative Commons: CC-BY-NC open in new tab

Keywords

Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Postępy Higieny i Medycyny Doświadczalnej no. 73, pages 269 - 281,
ISSN: 0032-5449
Language:
Polish
Publication year:
2019
Bibliographic description:
Zalewska-Piątek B., Piątek R., Krawczyk B., Olszewski M.: Patomechanizm zakażeń dróg moczowych wywoływanych przez uropatogenne szczepy E. coli// Postępy Higieny i Medycyny Doświadczalnej. -Vol. 73, (2019), s.269-281
DOI:
Digital Object Identifier (open in new tab) 10.5604/01.3001.0013.2022
Bibliography: test
  1. Postepy Hig Med Dosw (online), 2019; tom 73: 269-281 open in new tab
  2. Bradford P.A.: Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this im- portant resistance threat. Clin. Microbiol. Rev., 2001; 14: 933-951 open in new tab
  3. Carnoy C., Moseley S.L.: Mutational analysis of receptor binding mediated by the Dr family of Escherichia coli adhesins. Mol. Micro- biol., 1997; 23: 365-379 open in new tab
  4. Cassini A., Plachouras D., Eckmanns T., Abu Sin M., Blank H.P., Ducomble T., Haller S., Harder T., Klingeberg A., Sixtensson M., Ve- lasco E., Weiß B., Kramarz P, Monnet D.L., Kretzschmar M.E., Suetens C.: Burden of six healthcare-associated infections on European po- pulation health: estimating incidence-based disability-adjusted life years through a population prevalence-based modeling study. PLoS Med., 2016; 13: e1002150 open in new tab
  5. Caza M., Kronstad J.W.: Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans. Front. Cell. Infect. Microbiol., 2013; 3: 80 open in new tab
  6. Chassin C., Vimont S., Cluzeaud F., Bens M., Goujon J.M., Fer- nandez B., Hertig A., Rondeau E., Arlet G., Hornef M.W., Vandewalle A.: TLR4 facilitates translocation of bacteria across renal collecting duct cells. J. Am. Soc. Nephrol., 2008; 19: 2364-2374 open in new tab
  7. Chaturvedi K.S., Hung C.S., Crowley J.R., Stapleton A.E., Hen- derson J.P.: The siderophore yersiniabactin binds copper to protect pathogens during infection. Nat. Chem. Biol., 2012; 8: 731-736 open in new tab
  8. Chen Y.H., Ko W.C., Hsueh P.R.: Emerging resistance problems and future perspectives in pharmacotherapy for complicated uri- nary tract infections. Expert Opin. Pharmacother., 2013; 14: 587-596 open in new tab
  9. Chenoweth C.E . , Gould C.V., Saint S.: Diagnosis, management, and prevention of catheter-associated urinary tract infections. In- fect. Dis. Clin. North Am., 2014; 28: 105-119 open in new tab
  10. Chlabicz S., Leszczynska K., Lukas W., Gualco L., Schito G., Naber K.G.: Uncomplicated lower urinary tract infections in females -cli- nical aspects, aetiology and antimicrobial resistance epidemiology. Results of the ARESC (Antimicrobial Resistance Epidemiological Su- rvey on Cystitis) study in Poland and their implications for empiric therapy. Przegl. Epidemiol., 2011; 65: 345-51
  11. Chromek M . , Slamová Z., Bergman P., Kovács L., Podracká L., Eh- rén I., Hökfelt T., Gudmundsson G.H., Gallo R.L., Agerberth B., Brau- ner A.: The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat. Med., 2006; 12: 636-641 open in new tab
  12. Chue-Gonçalves M., Custódio C.C., Pelayo J.S., Nakazato G., Ko- bayashi R.K.: New approach for detection of Escherichia coli invasion to HeLa cells. J. Microbiol. Methods, 2018; 152: 31-35 open in new tab
  13. Conover M.S., Flores-Mireles A.L., Hibbing M.E., Dodson K., Hult- gren S.J.: Establishment and characterization of UTI and CAUTI in a mouse model. J. Vis. Exp., 2015; 100: e52892 open in new tab
  14. Cunningham P.N., Wang Y., Guo R., He G., Quigg R.J.: Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J. Im- munol., 2004; 172: 2629-2635 open in new tab
  15. Dhakal B.K., Mulvey M.A.: The UPEC pore-forming toxin α-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways. Cell Host Microbe, 2012; 11: 58-69 open in new tab
  16. Dodson K.W., Pinkner J.S., Rose T., Magnusson G., Hultgren S.J., Waksman G.: Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor. Cell, 2001; 105: 733-743 open in new tab
  17. Emödy L., Kerényi M., Nagy G.: Virulence factors of uropatho- genic Escherichia coli. Int. J. Antimicrob. Agents, 2003; 2: 29-33 open in new tab
  18. Eto D.S., Sundsbak J.L., Mulvey M.A.: Actin-gated intracellular growth and resurgence of uropathogenic Escherichia coli. Cell. Mi- crobiol., 2006; 8: 704-717 open in new tab
  19. Flores-Mireles A.L., Walker J.N., Caparon M., Hultgren S.J.: Uri- nary tract infections: epidemiology, mechanisms of infection and treatment options. Nat. Rev. Microbiol., 2015; 13: 269-284 open in new tab
  20. Foxman B.: Epidemiology of urinary tract infections: inci- dence, morbidity, and economic costs. Am. J. Med., 2002; 113 (Suppl. 1A): 5S-13S open in new tab
  21. Foxman B.: The epidemiology of urinary tract infection. Nat. Rev. Urol., 2010; 7: 653-660 open in new tab
  22. Foxman B.: Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden. Infect. Dis. Clin. North Am., 2014; 28: 1-13 open in new tab
  23. Garau J.: Other antimicrobials of interest in the era of ex- tended-spectrum beta-lactamases: fosfomycin, nitrofurantoin and tigecycline. Clin. Microbiol. Infect., 2008; 14 (Suppl 1): 198-202 open in new tab
  24. Garcia E.C., Brumbaugh A.R., Mobley H.L.: Redundancy and specificity of Escherichia coli iron acquisition systems during uri- nary tract infection. Infect. Immun., 2011; 79: 1225-1235 open in new tab
  25. Garcia M.I., Jouve M., Nataro J.P., Gounon P., Le Bouguénec C.: Characterization of the AfaD-like family of invasins encoded by pathogenic Escherichia coli associated with intestinal and extra- intestinal infections. FEBS Lett., 2000; 479: 111-117 open in new tab
  26. Garcia T.A., Ventura C.L., Smith M.A., Merrell D.S., O'Brien A.D.: Cytotoxic necrotizing factor 1 and hemolysin from uro- pathogenic Escherichia coli elicit different host responses in the murine bladder. Infect. Immun., 2013; 81: 99-109 open in new tab
  27. Geibel S., Waksman G.: The molecular dissection of the chap- erone-usher pathway. Biochim. Biophys. Acta, 2014; 1843: 1559- 1567 open in new tab
  28. Goluszko P., Moseley S.L., Truong L.D., Kaul A., Williford J.R., Selvarangan R., Nowicki S., Nowicki B.: Development of ex- perimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region pre- vented tubulointerstitial nephritis. J. Clin. Investig., 1997; 99: 1662-1672 open in new tab
  29. Goluszko P., Niesel D., Nowicki B., Selvarangan R., Nowicki S., Hart A., Pawelczyk E., Das M., Urvil P., Hasan R.: Dr operon- associated invasiveness of Escherichia coli from pregnant patients with pyelonephritis. Infect. Immun., 2001; 69: 4678-4680 open in new tab
  30. Goluszko P., Popov V., Selvarangan R., Nowicki S., Pham T., Nowicki B.J.: Dr fimbriae operon of uropathogenic Escherichia coli mediate microtubule-dependent invasion to the HeLa epithelial cell line. J. Infect. Dis., 1997; 176: 158-167 open in new tab
  31. Guglietta A.: Recurrent urinary tract infections in women: risk factors, etiology, pathogenesis and prophylaxis. Future Mi- crobiol., 2017; 12: 239-246 open in new tab
  32. Guignot J., Hudault S., Kansau I., Chau I., Servin A.L.: Human decay-accelerating factor and CEACAM receptor-mediated inter- nalization and intracellular lifestyle of Afa/Dr diffusely adhering Escherichia coli in epithelial cells. Infect. Immun., 2009; 77: 517-531 open in new tab
  33. Gupta K., Bhadelia N.: Management of urinary tract infec- tions from multidrug-resistant organisms. Infect. Dis. Clin. North Am., 2014; 28: 49-59 open in new tab
  34. Gupta K., Sahm D.F., Mayfield D., Stamm W.E.: Antimicrobial resistance among uropathogens that cause community-acquired urinary tract infections in women: A nationwide analysis. Clin. Infect. Dis., 2001; 33: 89-94 open in new tab
  35. Hannan T.J., Mysorekar I.U., Hung C.S., Isaacson-Schmid M.L., Hultgren S.J.: Early severe inflammatory responses to uropatho- genic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog., 2010; 6: e1001042 open in new tab
  36. Hannan T.J., Totsika M., Mansfield K.J., Moore K.H., Schembri M.A., Hultgren S.J.: Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escheri- chia coli bladder infection. FEMS Microbiol. Rev., 2012; 36: 616-648 open in new tab
  37. Hooton T.M.: Clinical practice. Uncomplicated urinary tract infection. N. Engl. J. Med., 2012; 366: 1028-1037 open in new tab
  38. Zalewska-Piątek B. i wsp. -Patomechanizm zakażeń dróg moczowych...
  39. Lo E., Nicolle L.E., Coffin S.E., Gould C., Maragakis L.L., Meddings J., Pegues D.A., Pettis A.M., Saint S., Yokoe D.S.: Strategies to prevent catheter-associated urinary tract infections in acute care hospitals. Infect. Control Hosp. Epidemiol., 2014; 35 (Suppl 2): S32-S47 open in new tab
  40. Martinez J.J., Hultgren S.J.: Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli. Cell. Microbiol., 2002; 4: 19-28 open in new tab
  41. Martinez J.J., Mulvey M.A., Schilling J.D., Pinkner J.S., Hultgren S.J.: Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. EMBO J., 2000; 19: 2803-2812 open in new tab
  42. Melican K . , Sandoval R.M., Kader A., Josefsson L., Tanner G.A., Molitoris B.A., Richter-Dahlfors A.: Uropathogenic Escherichia coli P and Type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstruction. PLoS Pathog. 2011; 7: e1001298 open in new tab
  43. Miao Y., Li G., Zhang X., Xu H., Abraham S.N.: A TRP channel senses lysosome neutralization by pathogens to trigger their expul- sion. Cell, 2015; 161: 1306-1319 open in new tab
  44. Miao Y., Wu J., Abraham S.N.: Ubiquitination of innate immune regulator TRAF3 orchestrates expulsion of intracellular bacteria by exocyst complex. Immunity, 2016; 45: 94-105 open in new tab
  45. Muenzner P., Kengmo Tchoupa A., Klauser B., Brunner T., Pu- tze J., Dobrindt U., Hauck C.R.: Uropathogenic E. coli exploit CEA to promote colonization of the urogenital tract mucosa. PLoS Pathog., 2016; 12: e1005608 open in new tab
  46. Mulvey M.A., Lopez-Boado Y.S., Wilson C.L., Roth R., Parks W.C., Heuser J., Hultgren S.J.: Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science, 1998; 282: 1494-1497 open in new tab
  47. Mulvey M.A., Schilling J.D., Hultgren S.J.: Establishment of a per- sistent Escherichia coli reservoir during the acute phase of a bladder infection. Infect. Immun., 2001; 69: 4572-4579 open in new tab
  48. Mysorekar I.U., Hultgren S.J.: Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract. Proc. Natl. Acad. Sci. USA, 2006; 103: 14170-14175 open in new tab
  49. Naber K.G., Schito G., Botto H., Palou J., Mazzei T.: Surveillance study in Europe and Brazil on clinical aspects and Antimicrobial Re- sistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy. Eur. Urol., 2008; 54: 1164-1175 open in new tab
  50. Nagamatsu K., Hannan T.J., Guest R.L., Kostakioti M., Hadjifran- giskou M., Binkley J., Dodson K., Raivio T.L., Hultgren S.J.: Dysregula- tion of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection. Proc. Natl. Acad. Sci. USA, 2015; 112: E871-E880 open in new tab
  51. Nielsen K.L., Dynesen P., Larsen P., Jakobsen L., Andersen P.S., Frimodt-Møller N.: Role of urinary cathelicidin LL-37 and human β-defensin 1 in uncomplicated Escherichia coli urinary tract infec- tions. Infect. Immun., 2014; 82: 1572-1578 open in new tab
  52. Nielubowicz G.R., Mobley H.L.: Host-pathogen interactions in urinary tract infection. Nat. Rev. Urol., 2010; 7: 430-441 open in new tab
  53. Nowicki B., Moulds J., Hull R., Hull S.: A hemagglutinin of uro- pathogenic Escherichia coli recognizes the Dr blood group antigen. Infect. Immun., 1988; 56: 1057-1060 open in new tab
  54. Nowicki B., Selvarangan R., Nowicki S.: Family of Escherichia coli Dr adhesins: decay-accelerating factor receptor recognition and in- vasiveness. J. Infect. Dis., 2001; 183 (Suppl. 1): S24-S27 open in new tab
  55. O'Brien V.P., Hannan T.J., Nielsen H.V., Hultgren S.J.: Drug and vaccine development for the treatment and prevention of urinary tract infections. Microbiol. Spectr., 2016; 4: 1-62 open in new tab
  56. Oelschlaeger T.A., Dobrindt U., Hacker J.: Pathogenicity islands of uropathogenic E. coli and the evolution of virulence. Int. J. Anti- microb. Agents, 2002; 19: 517-521 open in new tab
  57. Hung C.S., Bouckaert J., Hung D., Pinkner J., Widberg C., DeFus- co A., Auguste C.G., Strouse R., Langermann S., Waksman G., Hult- gren S.J.: Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Mol. Microbiol., 2002; 44: 903-915 open in new tab
  58. Hung C.S., Dodson K.W., Hultgren S.J.: A murine model of uri- nary tract infection. Nat. Protoc., 2009; 4: 1230-1243 open in new tab
  59. Hunstad D.A., Justice S.S.: Intracellular lifestyles and immune evasion strategies of uropathogenic Escherichia coli. Annu. Rev. Mi- crobiol., 2010; 64: 203-221 open in new tab
  60. Jacobsen S.M., Stickler D.J., Mobley H.L., Shirtliff M.E.: Com- plicated catheter-associated urinary tract infections due to Esche- richia coli and Proteus mirabilis. Clin. Microbiol. Rev., 2008; 21: 26-59 open in new tab
  61. Justice S.S., Hung C., Theriot J.A., Fletcher D.A., Anderson G.G., Footer M.J., Hultgren S.J.: Differentiation and developmental path- ways of uropathogenic Escherichia coli in urinary tract pathogen- esis. Proc. Natl. Acad. Sci. USA, 2004; 101: 1333-1338 open in new tab
  62. Justice S.S., Hunstad D.A.: UPEC hemolysin: more than just for making holes. Cell Host Microbe, 2012; 11: 4-5 open in new tab
  63. Justice S.S., Hunstad D.A., Seed P.C., Hultgren S.J.: Filamenta- tion by Escherichia coli subverts innate defenses during urinary tract infection. Proc. Natl. Acad. Sci. USA, 2006; 103: 19884-19889 open in new tab
  64. Kahlmeter G., Poulsen H.O.: Antimicrobial susceptibility of Escherichia coli from community-acquired urinary tract infections in Europe: the ECO·SENS study revisited. Int. J. Antimicrob. Agents, 2012; 39: 45-51 open in new tab
  65. Kline K.A., Schwartz D.J., Lewis W.G., Hultgren S.J., Lewis A.L.: Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection. Infect. Immun., 2011; 79: 3588-3595 open in new tab
  66. Korhonen T.K, Parkkinen J., Hacker J., Finne J., Pere A., Rhen M., Holthöfer H.: Binding of Escherichia coli S fimbriae to human kidney epithelium. Infect. Immun., 1986; 54: 322-327 open in new tab
  67. Korotkova N., Yang Y., Le Trong I., Cota E., Demeler B., March- ant J., Thomas W.E., Stenkamp R.E., Moseley S.L., Matthews S.: Bind- ing of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation. Mol. Microbiol., 2008; 67: 420-434 open in new tab
  68. Korotkova N., Yarova-Yarovaya Y., Tchesnokova V., Yazvenko N., Carl M.A., Stapleton A.E., Moseley S.L.: Escherichia coli DraE ad- hesin-associated bacterial internalization by epithelial cells is pro- moted independently by decay-accelerating factor and carcinoem- bryonic antigen-related cell adhesion molecule binding and does not require the DraD invasin. Infect. Immun., 2008; 76: 3869-3880 open in new tab
  69. Kot B., Wicha J., Żak-Puławska Z.: Susceptibility of Escherichia coli strains isolated from persons with urinary tract infections in 2007-2008 to antimicrobial agents. Przegl. Epidemiol., 2010; 64: 307-312
  70. Landraud L., Pulcini C., Gounon P., Flatau G., Boquet P., Lemi- chez E.: E. coli CNF1 toxin: a two-in-one system for host-cell inva- sion. Int. J. Med. Microbiol., 2004; 293: 513-518 open in new tab
  71. Le Bouguénec C., Servin, A.L.: Diffusely adherent Escherichia coli strains expressing Afa/Dr adhesins (Afa/Dr DAEC): hitherto unrecognized pathogens. FEMS Microbiol. Lett., 2006; 256: 185-194 open in new tab
  72. Leffler H., Svanborg-Edén C.: Glycolipid receptors for uro- pathogenic Escherichia coli on human erythrocytes and uroepithe- lial cells. Infect. Immun., 1981; 34: 920-929 open in new tab
  73. Levison M.E., Kaye D.: Treatment of complicated urinary tract infections with an emphasis on drug-resistant gram-negative uro- pathogens. Curr. Infect. Dis. Rep., 2013; 15: 109-115 open in new tab
  74. Lewis A.J. Richards A.C., Mulvey M.A.: Invasion of host cells and tissues by uropathogenic bacteria. Microbiol. Spectr., 2016; 4: 1-29 open in new tab
  75. Lichtenberger P., Hooton T.M.: Complicated urinary tract in- fections. Curr. Infect. Dis. Rep., 2008; 10: 499-504 open in new tab
  76. Postepy Hig Med Dosw (online), 2019; tom 73: 269-281 open in new tab
  77. Song J., Bishop B.L., Li G., Duncan M.J., Abraham S.N.: TLR4- initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host Microbe, 2007; 1: 287-298 open in new tab
  78. Song J., Bishop B.L., Li G., Grady R., Stapleton A., Abraham S.N.: TLR4-mediated expulsion of bacteria from infected bladder epithe- lial cells. Proc. Natl. Acad. Sci. USA, 2009; 106: 14966-14971 open in new tab
  79. Spaulding C.N., Schreiber H.L. 4th, Zheng W., Dodson K.W., Ha- zen J.E., Conover M.S., Wang F., Svenmarker P., Luna-Rico A., France- tic O., Andersson M., Hultgren S., Egelman E.H.: Functional role of the type 1 pilus rod structure in mediating host-pathogen interac- tions. eLife, 2018; 7: e31662 open in new tab
  80. Stamm W.E., Norrby S.R.: Urinary tract infections: disease pa- norama and challenges. J. Infect. Dis., 2001; 183 (Suppl 1): S1-S4 open in new tab
  81. Terlizzi M.E., Gribaudo G., Maffei M.E.: UroPathogenic Esche- richia coli (UPEC) Infections: virulence factors, bladder responses, antibiotic, and non-antibiotic antimicrobial strategies. Front. Mi- crobiol., 2017; 8: 1566 open in new tab
  82. Thankavel K., Madison B., Ikeda T., Malaviya R., Shah A.H., Aru- mugam P.M., Abraham S.N.: Localization of a domain in the FimH adhesin of Escherichia coli type 1 fimbriae capable of receptor reco- gnition and use of a domain-specific antibody to confer protection against experimental urinary tract infection. Clin. Invest., 1997; 100: 1123-1136 open in new tab
  83. Thurston T.L., Wandel M.P., von Muhlinen N., Foeglein A., Ran- dow F.: Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature, 2012; 482: 414-418 open in new tab
  84. Valdebenito M., Crumbliss A.L., Winkelmann G., Hantke K.: Environmental factors influence the production of enterobactin, salmochelin, aerobactin, and yersiniabactin in Escherichia coli strain Nissle 1917. Int. J. Med. Microbiol., 2006; 296: 513-520 open in new tab
  85. Vallet I., Olson J.W., Lory S., Lazdunski A., Filloux A.: The cha- perone/usher pathways of Pseudomonas aeruginosa: identification of fimbrial gene clusters (cup) and their involvement in biofilm forma- tion. Proc. Natl. Acad. Sci. USA, 2001; 98: 6911-6916 open in new tab
  86. Valore E.V., Park C.H., Quayle A.J., Wiles K.R., McCray P.B. Jr, Ganz T.: Human beta-defensin-1: an antimicrobial peptide of uro- genital tissues. J. Clin. Invest., 1998; 101: 1633-1642 open in new tab
  87. Waksman G., Hultgren S.J.: Structural biology of the chape- rone-usher pathway of pilus biogenesis. Nat. Rev. Microbiol., 2009; 7: 765-774 open in new tab
  88. Wankel B . , Ouyang J., Guo X., Hadjiolova K., Miller J., Liao Y., Tham D.K., Romih R., Andrade L.R., Gumper I., Simon J.P., Sachdeva R., Tolmachova T., Seabra M.C., Fukuda M. i wsp.: Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells. Mol. Biol. Cell, 2016; 27: 1621-1634 open in new tab
  89. Watts R.E., Totsika M., Challinor V.L., Mabbett A.N., Ulett G.C., De Voss J.J., Schembri M.A.: Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli. Infect. Immun., 2012; 80: 333-344 open in new tab
  90. Werneburg G.T., Thanassi D.G.: Pili assembled by the chape- rone/usher pathway in Escherichia coli and Salmonella. EcoSal Plus, 2018; 8: 1-37 open in new tab
  91. Wróblewska-Seniuk K., Selvarangan R., Hart A., Pladzyk R., Goluszko P., Jafari A., du Merle L., Nowicki S., Yallampalli C., Le Bo- uguénec C., Nowicki B.: Dra/AfaE adhesin of uropathogenic Dr/Afa + Escherichia coli mediates mortality in pregnant rats. Infect. Immun., 2005; 73: 7597-7601 open in new tab
  92. Wurpel D.J., Beatson S.A., Totsika M, Petty N.K., Schembri M.A.: Chaperone-usher fimbriae of Escherichia coli. PLoS One, 2013; 8: e52835 open in new tab
  93. Yamamoto S.: Molecular epidemiology of uropathogenic Esche- richia coli. J. Infect. Chemother., 2007; 13: 68-73 open in new tab
  94. Paterson D.L.: Resistance in gram-negative bacteria: Enterobac- teriaceae. Am. J. Infect. Control, 2006; 34 (5 Suppl 1): S20-S28 open in new tab
  95. Pendleton J.N., Gorman S.P., Gilmore B.F.: Clinical relevance of the ESKAPE pathogens. Expert Rev. Anti Infect. Ther., 2013; 11: 297-308 open in new tab
  96. Pere A., Leinonen M., Väisänen-Rhen V., Rhen M., Korhonen T.K.: Occurrence of type-1C fimbriae on Escherichia coli strains iso- lated from human extraintestinal infections. J. Gen. Microbiol., 1985; 131: 1705-1711 open in new tab
  97. Piątek R., Zalewska B., Kolaj O., Ferens M., Nowicki B., Kur J.: Mo- lecular aspects of biogenesis of Escherichia coli Dr fimbriae: charac- terization of DraB-DraE complexes. Infect. Immun., 2005; 73: 135-145
  98. Raz R., Gennesin Y., Wasser J., Stoler Z., Rosenfeld S., Rotten- sterich E., Stamm W.E.: Recurrent urinary tract infections in post- menopausal women. Clin. Infect. Dis., 2000; 30: 152-156 open in new tab
  99. Reigstad C.S., Hultgren S.J., Gordon J.I.: Functional genomic studies of uropathogenic Escherichia coli and host urothelial cells when intracellular bacterial communities are assembled. J. Biol. Chem., 2007; 282: 21259-21267 open in new tab
  100. Roberts J.A., Marklund B.I., Ilver D., Haslam D., Kaack M.B., Baskin G., Louis, M., Möllby R., Winberg J., Normark S.: The Gal(alpha open in new tab
  101. Gal-specific tip adhesin of Escherichia coli P-fimbriae is needed for pyelonephritis to occur in the normal urinary tract. Proc. Natl. Acad. Sci. USA, 1994; 91: 11889-11893 open in new tab
  102. Robino L., Scavone P., Araujo L., Algorta G., Zunino P., Pírez M.C., Vignoli R.: Intracellular bacteria in the pathogenesis of Esche- richia coli urinary tract infection in children. Clin. Infect. Dis., 2014; 59: e158-e164 open in new tab
  103. Rogers B.A., Sidjabat H.E., Paterson D.L.: Escherichia coli O25b- ST131: a pandemic, multiresistant, community-associated strain. J. Antimicrob. Chemother., 2011; 66: 1-14 open in new tab
  104. Ronald A.: The etiology of urinary tract infection: traditional and emerging pathogens. Dis. Mon., 2003; 49: 71-82 open in new tab
  105. Rosen D.A., Hooton T.M., Stamm W.E., Humphrey P.A., Hultgren S.J.: Detection of intracellular bacterial communities in human uri- nary tract infection. PLoS Med., 2007; 4: e329 open in new tab
  106. Russo T.A., Stapleton A., Wenderoth S., Hooton T.M., Stamm W.E.: Chromosomal restriction fragment length polymorphism analysis of Escherichia coli strains causing recurrent urinary tract infections in young women. J. Infect. Dis., 1995; 172: 440-445 open in new tab
  107. Salvatore S., Salvatore S., Cattoni E., Siesto G., Serati M., Sorice P., Torella M.: Urinary tract infections in women. Eur. J. Obstet. Gy- necol. Reprod. Biol., 2011; 156: 131-136 open in new tab
  108. Scholes D., Hooton T.M., Roberts P.L. Stapleton A.E., Gupta K., Stamm W.E.: Risk factors for recurrent urinary tract infection in young women. J. Infect. Dis., 2000; 182: 1177-1182 open in new tab
  109. Schwartz D.J., Chen S.L., Hultgren S.J., Seed P.C.: Population dynamics and niche distribution of uropathogenic Escherichia coli during acute and chronic urinary tract infection. Infect. Immun., 2011; 79: 4250-4259 open in new tab
  110. Selvarangan R., Goluszko P., Singhal J., Carnoy C., Moseley S., Hudson B., Nowicki S., Nowicki B.: Interaction of Dr adhesin with collagen type IV is a critical step in Escherichia coli renal persistence. Infect. Immun., 2004; 72: 4827-4835 open in new tab
  111. Servin A.L.: Pathogenesis of Afa/Dr diffusely adhering Escheri- chia coli. Clin. Microbiol. Rev., 2005; 18: 264-292 open in new tab
  112. Smaill F., Vazquez J.C.: Antibiotics for asymptomatic bacteri- uria in pregnancy. Cochrane Database Syst. Rev., 2007; 2: CD000490 open in new tab
  113. Sokurenko E.V., Chesnokova V., Doyle R.J, Hasty D.L.: Diversity of the Escherichia coli type 1 fimbrial lectin. Differential binding to mannosides and uroepithelial cells. J. Biol. Chem., 1997; 272: 17880-17886 open in new tab
  114. Zalewska-Piątek B. i wsp. -Patomechanizm zakażeń dróg moczowych...
  115. Zavialov A., Zav'yalova G., Korpela T., Zav'yalov V.: FGL chapero- ne-assembled fimbrial polyadhesins: anti-immune armament of Gram- -negative bacterial pathogens. FEMS Microbiol. Rev., 2007; 31: 478-514 open in new tab
  116. Zowawi H.M., Harris P.N., Roberts M.J., Tambyah P.A., Schembri M.A., Pezzani M.D., Williamson D.A., Paterson D.L.: The emerging thre- at of multidrug-resistant Gram-negative bacteria in urology. Nat. Rev. Urol., 2015; 12: 570-584 open in new tab
  117. Autorzy deklarują brak potencjalnych konfliktów inte- resów. open in new tab
  118. Zalewska-Piątek B., Bury K., Piątek R., Bruździak P., Kur J.: Type II secretory pathway for surface secretion of DraD invasin from the uropathogenic Escherichia coli Dr + strain. J. Bacteriol., 2008; 190: 5044-5056 open in new tab
  119. Zalewska-Piątek B., Piątek R., Olszewski M., Kur J.: Identifi- cation of antigen Ag43 in uropathogenic Escherichia coli Dr + strains and defining its role in the pathogenesis of urinary tract infections. Microbiology, 2015; 161:1034-1049 open in new tab
  120. Zalewska Piątek B.M., Wilkanowicz S.I., Piątek R.J., Kur J.W.: Bio- film formation as a virulence determinant of uropathogenic Escheri- chia coli Dr + strains. Pol. J. Microbiol., 2009; 58: 223-229
Sources of funding:
  • Statutory activity/subsidy
Verified by:
Gdańsk University of Technology

seen 615 times

Recommended for you

Meta Tags