Search
Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber
Abstract
Ulcerative colitis (UC) is a main form of inflammatory bowel disease (IBD). Asafoetida (ASF) and turmeric have traditionally been used for the treatment of various inflammatory diseases, including UC, because ASF is rich in sulfur compounds and turmeric contains curcumin (CUR). Turmeric nanofiber (TNF), the modified cell wall component of turmeric is considered to play important role in the human diet, health and can be used as a carrier agent to encapsulate bioactive components. A novel gut health product (GHP) was formulated by encapsulation of ASF and CUR complex onto TNF. The GHP was characterized by UPLC, GC-MS, FTIR, XRD, SEM with EDS and DSC studies. GHP was evaluated for anti-colitis activity in a rat model of 5% dextran sulfate sodium (DSS) induced UC. Treatment with GHP significantly attenuated the disease activity index, colitis score, histopathological changes and myeloperoxidase activity. GHP has significant protective effects against DSS induced colitis.
Citations
-
3 9
CrossRef
-
0
Web of Science
-
3 8
Scopus
Authors (7)
-
Sreeraj Gopi
-
Augustine Amalraj
-
Shintu Jude
-
Karthik Varma
-
T.r. Sreeraj
-
Sabu Thomas
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
Materials Science & Engineering C-Materials for Biological Applications
no. 81,
pages 20 - 31,
ISSN: 0928-4931 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Gopi S., Amalraj A., Jude S., Varma K., Sreeraj T., Haponiuk J., Thomas S.: Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber// Materials Science & Engineering C-Materials for Biological Applications. -Vol. 81, (2017), s.20-31
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.msec.2017.07.037
- Verified by:
- Gdańsk University of Technology
seen 154 times
Recommended for you
Population-based case-control study of alpha 1-antitrypsin and SLC11A1 in Crohn's disease and ulcerative colitis.
- R. Kotłowski,
- C. Bernstein,
- M. Silverberg
- + 1 authors
Microbial diversity of inflamed and noninflamed gut biopsy tissues in inflammatory bowel disease.
- S. Shadi,
- R. Kotłowski,
- C. Bernstein
- + 1 authors
Genetic predisposition to inflammatory bowel disease
- B. Ferra,
- M. Góra-Gębka,
- R. Kotłowski
- + 2 authors
High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
- R. Kotłowski,
- C. Bernstein,
- S. Sepehri
- + 1 authors