Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation

Teemo Myllylä; Erkki Vihriälä; Matteo Pedone; Vesa Korhonen; Łukasz Surażyński; Maciej Wróbel; Aleksandra Zienkiewicz; Jaakko Hakala; Hannu Sorvoja; Janne Lauri; Tapio Fabritius; Małgorzata Szczerska; Vesa Kiviniemi; Igor Meglinski

doi:10.1117/12.2251977

Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation

Abstract

In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.

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Authors (14)

Teemo Myllylä
- University of Oulu
Erkki Vihriälä
- University of Oulu
Matteo Pedone
- University of Oulu
Vesa Korhonen
- University of Oulu
Łukasz Surażyński
- University of Oulu
Maciej Wróbel dr inż.
Aleksandra Zienkiewicz
- University of Oulu
Jaakko Hakala
- University of Oulu
Hannu Sorvoja
- University of Oulu
Janne Lauri
- University of Oulu
Tapio Fabritius
- University of Oulu
Małgorzata Szczerska prof. dr hab. inż.
Vesa Kiviniemi
- University of Oulu
Igor Meglinski
- University of Oulu

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materiały konferencyjne indeksowane w Web of Science

Title of issue:

Conference on Dynamics and Fluctuations in Biomedical Photonics XIV

Language:

English

Publication year:

2017

Bibliographic description:

Myllylä T., Vihriälä E., Pedone M., Korhonen V., Surażyński Ł., Wróbel M., Zienkiewicz A., Hakala J., Sorvoja H., Lauri J., Fabritius T., Szczerska M., Kiviniemi V., Meglinski I..: Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation, W: Conference on Dynamics and Fluctuations in Biomedical Photonics XIV, 2017, ,.

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