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Abstract
In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.
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Authors (14)
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Teemo Myllylä
- University of Oulu
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Erkki Vihriälä
- University of Oulu
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Matteo Pedone
- University of Oulu
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Vesa Korhonen
- University of Oulu
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Jaakko Hakala
- University of Oulu
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Hannu Sorvoja
- University of Oulu
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Janne Lauri
- University of Oulu
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Tapio Fabritius
- University of Oulu
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Vesa Kiviniemi
- University of Oulu
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Igor Meglinski
- University of Oulu
Cite as
Full text
- Publication version
- Accepted or Published Version
- License
- Copyright (2017 SPIE)
Keywords
Details
- Category:
- Conference activity
- Type:
- materiały konferencyjne indeksowane w Web of Science
- Title of issue:
- Conference on Dynamics and Fluctuations in Biomedical Photonics XIV
- Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Myllylä T., Vihriälä E., Pedone M., Korhonen V., Surażyński Ł., Wróbel M., Zienkiewicz A., Hakala J., Sorvoja H., Lauri J., Fabritius T., Szczerska M., Kiviniemi V., Meglinski I..: Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation, W: Conference on Dynamics and Fluctuations in Biomedical Photonics XIV, 2017, ,.
- DOI:
- Digital Object Identifier (open in new tab) 10.1117/12.2251977
- Verified by:
- Gdańsk University of Technology
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