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Abstract
Carbohydrate polymers, including Chitosan, Cellulose, Starch, Dextran, Pectin, Alginate, and Hyaluronic Acid, have been considered as stimuli-responsive biopolymers demonstrating significant potential for drug delivery approaches. Relying on the specific design and fabrication, such biopolymers are able to respond to fluctuations in pH, temperature, or enzymatic activity. This review investigates stimuli-responsive biopolymers, known as carbohydrate polymers, mainly chitosan, cellulose, and alginate, utilized as drug delivery approaches, emphasizing that these stimuli-responsive biopolymers accelerate controlled drug release. The pH-responsive delivery systems selectively target acidic tumor microenvironments, while temperature-responsive materials provide precise control for drug release produced by hyperthermia. Light-responsive biopolymers provide spatial and temporal control, providing appropriate for targeted therapy. Redox-responsive structures are especially efficient in responding to elevated glutathione (GSH) in tumor microenvironment, facilitating targeted drug release. Electro- and magnetic-responsive systems provide remote control functionalities, improving the accuracy of drug administration. The incorporation of multi-stimuli-responsive mechanisms implies a remarkable progression in drug delivery, providing a more versatile and adaptable framework for therapeutic applications. Accordingly, the future research on carbohydrate polymer-based stimuli-responsive delivery systems should focus on improving the responsiveness and targeting efficacy through complicated optimization of features and performance of carbohydrate polymers, where the integration of multifunctional moieties facilitates transformation of targeted drugs for broader biological functions.
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Authors (14)
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Hossein Madineh
- Polymer Engineering Department, Chemical Engineering Faculty, Tarbiat Modares University, Tehran, Iran
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Fatemeh Mansourinia
- Polymer Engineering Department, Chemical Engineering Faculty, Tarbiat Modares University, Tehran, Iran
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Payam Zarrintaj
- E3 LLC, Louisville, KY, USA
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Mehdi Ghaffari
- Polymer Group, Faculty of Technical and Engineering, Golestan University, P. O. Box 155, Gorgan, Golestan, Iran
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Mohamed S. Hasanin
- Cellulose and Paper Department, National Research Centre, 33 El Bohouth St., Cairo 12622, Egypt
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Sharanappa Chapi
- Department of Physics, B.M.S. College of Engineering, Basavanagudi - 560019, Bengaluru, Karnataka, India
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Milad Ashrafizadeh
- Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
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Tomasz Baczek
- Department of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, 80-416 Gdańsk, Poland
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Mohammad Reza Saeb
- Department of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, 80-416 Gdańsk, Poland
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Guizhen Wang
- Department of Emergency, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai 200072, China
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Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
no. 310,
ISSN: 0141-8130 - Language:
- English
- Publication year:
- 2025
- Bibliographic description:
- Madineh H., Mansourinia F., Zarrintaj P., Poostchi M., Gnatowski P., Kucińska-Lipka J., Ghaffari M., Hasanin M. S., Chapi S., Khodadadiyazdi M., Ashrafizadeh M., Baczek T., Saeb M. R., Wang G.: Stimuli-responsive delivery systems using carbohydrate polymers: A review// INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES -Vol. 310, (2025), s.142648-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.ijbiomac.2025.142648
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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