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Abstract
Recently we have focused in the problem of preparation of carbamoylo-β-lactams as a result of oxidative cyclization of malonyl enamides. In our experiments we obtain mixture of two main β-lactam products: as a result of subsequent elimination and a second as a product of substitution. All of the produced β-lactams have trans configuration what was confirmed by 1H coupling constants. However id should be stressed that in the case of substitution product, a new chiral center is generated, leading to formation of two pair of diastereoisomers.For elucidate their structures we used ROESY and NOESY experiments. Correlations between β-lactam protons and a methyl group allowed to assign structures of pairs of diastereisomers.
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- Category:
- Other
- Type:
- supllement, wydanie specjalne, dodatek
- Published in:
-
Acta Biochimica Polonica
no. 58,
ISSN: 0001-527X - Title of issue:
- Acta Biochimica Polonica.
- Language:
- English
- Publication year:
- 2011
- Bibliographic description:
- Punda P., Janikowska K., Makowiec S.: Structure elucidation of carbamoylo-β-lactam diastereoisomers by ROESY and NOESY experiments// Acta Biochimica Polonica. -Vol. 58., nr. Suppl. 4 (2011),
- Verified by:
- Gdańsk University of Technology
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