Search
Structure, Physicochemical and Biological Properties of an Aqua (2,2′,2′′-Nitrilotriacetato)-oxidovanadium(IV) Salt with 4-Methylpyridinium Cation
Abstract
The crystal structure of a nitrilotriacetate (nta) oxidovanadi-um(IV) salt with 4-methylpyridinium cation, [4-Me(Py)H]+, of [4-Me(Py)H][VO(nta)(H2O)] stoichiometry was determined. The com-plex comprises a discrete mononuclear [VO(nta)(H2O)]–coordinationentity that can be rarely found among other known compounds con-taining nitrilotriacetate oxidovanadium(IV) moieties. The complex wascharacterized by spectroscopic (IR and EPR) methods, magnetic mea-surements, and thermogravimetry (TG-FTIR). The stability of the titlecompound in aqueous solutions was investigated by using the potentio-metric titration method. Furthermore, spectrophotometric (UV/Vis)studies have revealed that the compound is capable to scavenge the superoxide free radicals (O2•–) as well as stable organic radicals i.e.2,2⬘-azinobis(3-ethylbenzothiazoline-6 sulfonic acid) cation radical(ABTS+•) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•). Finally,biological properties of the complex studied were investigated in rela-tion to its cytoprotective activity against the oxidative damage gener-ated exogenously by using hydrogen peroxide in the HT22 hippocam-pal neuronal cell line (the MTT assay). Additionally, the biologicalaction of the compound towards two human osteosarcoma HOS andMG-63 cell lines (the MTT and BrdU tests) as well as the untrans-formed human osteoblast hFOB 1.19 cell line was tested.
Citations
-
5
CrossRef
-
0
Web of Science
-
4
Scopus
Authors (9)
-
Dariusz Wyrzykowski
- Faculty of ChemistryUniversity of Gdan´sk
-
Julia Kłak
- Faculty of ChemistryWrocław University
-
Kowalski Szymon
- Department of Medical ChemistryMedical University of Gdan´sk
-
Iwona Inkielewicz-Stępniak
- Department of Medical ChemistryMedical University of Gdan´sk
-
Joanna Drzeżdżon
- Faculty of ChemistryUniversity of Gdan´sk
-
Dagmara Jacewicz
- Faculty of ChemistryUniversity of Gdan´sk
-
Lech Chmurzyński
- Faculty of ChemistryUniversity of Gdan´sk
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
no. 643,
edition 7,
pages 501 - 510,
ISSN: 0044-2313 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Tesmar A., Wyrzykowski D., Kazimierczuk K., Kłak J., Szymon K., Inkielewicz-Stępniak I., Drzeżdżon J., Jacewicz D., Chmurzyński L.: Structure, Physicochemical and Biological Properties of an Aqua (2,2′,2′′-Nitrilotriacetato)-oxidovanadium(IV) Salt with 4-Methylpyridinium Cation// ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE. -Vol. 643, iss. 7 (2017), s.501-510
- DOI:
- Digital Object Identifier (open in new tab) 10.1002/zaac.201700022
- Verified by:
- Gdańsk University of Technology
seen 116 times
Recommended for you
Exploring the Antitumor Efficacy of N-Heterocyclic Nitrilotriacetate Oxidovanadium(IV) Salts on Prostate and Breast Cancer Cells
- K. Chmur,
- A. Tesmar,
- M. Zdrowowicz
- + 3 authors
Synthesis of 3-(2-Alkylthio-4-chloro-5-methylbenzenesulfonyl)-2-(1-phenyl-3-arylprop-2-enylideneamino)guanidine Derivatives with Pro-Apoptotic Activity against Cancer Cells
- A. Pogorzelska,
- J. Sławiński,
- A. Kawiak
- + 2 authors
Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells
- S. Nair,
- A. Sasidharan,
- V. D. Rani
- + 4 authors