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Abstract
In search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally, the cytotoxic properties depends on the substituent and configuration at chiral center in amino acid unit. Three derivatives revealed higer potency than parent MPA.
Authors (5)
-
Piotr Trzonkowski
- Gdański Uniwersytet Medyczny/Wydział Lekarski z Oddziałem Stomatologicznym Katedra Immunologii
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.ejmech.2013.09.026
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
no. 69,
pages 863 - 871,
ISSN: 0223-5234 - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Iwaszkiewicz-Grześ D., Cholewiński G., Kot-Wasik A., Trzonkowski P., Dzierzbicka K.: Synthesis and biological activity of mycophenolic acid-amino acid derivatives// EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. -Vol. 69, (2013), s.863-871
- Verified by:
- Gdańsk University of Technology
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