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The biological role of prolyl oligopeptidase and the procognitive potential of its peptidic inhibitors from food proteins
Abstract
Prolyl oligopeptidase (POP) is a conserved serine protease belonging to proline-specific peptidases. It has both enzymatic and non-enzymatic activity and is involved in numerous biological processes in the human body, playing a role in e.g., cellular growth and differentiation, inflammation, as well as the development of some neurodegenerative and neuropsychiatric disorders. This article describes the physiological and pathological aspects of POP activity and the state-of-art of its peptidic inhibitors originating from food proteins, with a particular focus on their potential as cognition-enhancing agents. Although some milk, meat, fish, and plant protein-derived peptides have the potential to be applied as natural, procognitive nutraceuticals, their effectiveness requires further evaluation, especially in clinical trials. We demonstrated that the important features of the most promising POP-inhibiting peptides are very short sequence, high content of hydrophobic amino acids, and usually the presence of proline residue.
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/10408398.2023.2170973
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
no. 64,
pages 6567 - 6580,
ISSN: 1040-8398 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Taraszkiewicz A., Sinkiewicz I., Sommer A., Staroszczyk H.: The biological role of prolyl oligopeptidase and the procognitive potential of its peptidic inhibitors from food proteins// CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION -Vol. 64,iss. 19 (2024), s.6567-6580
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/10408398.2023.2170973
- Sources of funding:
- Verified by:
- Gdańsk University of Technology
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