Search
Abstract
Polyurethane hydrogels are potentially attractive materials for biomedical applications. They are able to absorb large amount of water, biological fluids or active substances, and thus, they have potential to be used as absorbents or wound-healing dressings. They are also used for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. The presence of organofillized montmorillonite (Cloisite® 30B) in polyurethane nanocomposite hydrogels remarkably improves the swelling capability, but on the other hand slows down the release process of an active substance from the matrix. The swelling of paracetamol solution by the nanocomposite matrix and the release process of this active substance from the hydrogel were investigated using gravimetric analysis and spectroscopic method. The kinetics of both these processes were accurately analyzed by the use of Korsmeyer–Peppas and modified Hopfenberg and Weibull models. In the present paper, three different nanocomposite systems with various amounts of Cloisite® 30B were studied. The results of these studies confirm beneficial impact of the nanosize effect on the drug diffusion processes in polyurethane nanocomposite hydrogels.
Citations
-
1 2
CrossRef
-
0
Web of Science
-
1 6
Scopus
Authors (5)
-
Marta Motke mgr
-
Justyna Strankowska
-
Jerzy Kwela
-
Marek Józefowicz
Cite as
Full text
- Publication version
- Accepted or Published Version
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
POLYMER BULLETIN
no. 77,
pages 483 - 499,
ISSN: 0170-0839 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Motke M., Strankowska J., Kwela J., Józefowicz M., Strankowski M.: Transport of paracetamol in swellable and relaxing polyurethane nanocomposite hydrogels// POLYMER BULLETIN -Vol. 77, (2020), s.483-499
- DOI:
- Digital Object Identifier (open in new tab) 10.1007/s00289-019-02755-6
- Verified by:
- Gdańsk University of Technology
seen 211 times
Recommended for you
Transport Mechanism of Paracetamol (Acetaminophen) in Polyurethane Nanocomposite Hydrogel Patches—Cloisite® 30B Influence on the Drug Release and Swelling Processes
- J. Strankowska,
- M. Grzywińska,
- E. Łęgowska
- + 2 authors
Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels
- M. Miotke,
- J. Strankowska,
- J. Kwela
- + 4 authors
Molecular dynamics studies of polyurethane nanocomposite hydrogels
- J. Strankowska,
- Ł. Piszczyk,
- M. Strankowski
- + 4 authors