Search results for: MOLECULAR TARGETS - Bridge of Knowledge

Search

Search results for: MOLECULAR TARGETS

Best results in : Research Potential Pokaż wszystkie wyniki (21)

Search results for: MOLECULAR TARGETS

Best results in : Business Offer Pokaż wszystkie wyniki (2)

Search results for: MOLECULAR TARGETS

Other results Pokaż wszystkie wyniki (135)

Search results for: MOLECULAR TARGETS

  • Molecular Targets for Anticandidal Chemotherapy

    Publication

    - Year 2017

    A relatively small number of anticandidal chemotherapeutics used in clinical practice is at least in part consequence of a limited number of their molecular targets: ergosterol in the membrane, lanosterol demethylase, b(1!3) glucan synthase, and DNA/RNA biosynthesis. Much more potential novel targets have been revealed by the comparative genomic studies identifying essential genes unique for Candida albicans or resulted from recognition...

    Full text to download in external service

  • Molecular targets for antifungals in amino acid and protein biosynthetic pathways

    Publication

    Fungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. In the last few years, increasing importance is attached to the health and economic problems...

    Full text available to download

  • New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets

    Publication

    - Pharmaceutics - Year 2022

    Infections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...

    Full text available to download

  • TIME-OF-FLIGHT DIFFERENTIAL ELECTRON SCATTERING FROM MOLECULAR TARGETS: BENCHMARK CROSS SECTIONS

    Publication

    - Year 2023

    We report time-of-flight differential cross section (DCS) measurements for the electron impact excitation transition in H2. In this work, agreement between available theory and experiment is excellent overall, and marks a transition in electron molecule scattering where differential scattering of excitation is found to be in such precise agreement. We also prove that the newly built apparatus can be used for accurate measurement...

    Full text to download in external service

  • Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

    Publication
    • A. Janaszak-Jasiecka
    • A. Płoska
    • J. M. Wierońska
    • L. W. Dobrucki
    • L. Kalinowski

    - CELLULAR & MOLECULAR BIOLOGY LETTERS - Year 2023

    Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark of endothelial dysfunction underlying the patho‑ genesis of the cardiovascular disease. Vascular NO is synthesized by endothelial nitric oxide synthase (eNOS) from the substrate L‑arginine (L‑Arg), with tetrahydrobiopterin...

    Full text available to download