prof. dr hab. inż. Dariusz Witt
Social media
Contact
- chemwitt@pg.edu.pl
Professor
- Workplace
- Budynek A Wydziału Chemicznego pokój 105
- Phone
- (58) 347 18 51
Publication showcase
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Recent Developments in the Synthesis of Unsymmetrical Disulfanes (Disulfides). A Review
The synthesis of unsymmetrical disulfanes is an important transformation in organic synthesis and medicinal chemistry. The current review is intended to summarize achievements in the synthesis of unsymmetrical disulfanes over the last decade (2004–2014).
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Functionalization of cysteine derivatives by unsymmetrical disulfide bond formation
Opracowano metodę funkcjonalizacji pochodnych cysteiny przy pomocy tworzenia niesymetrycznego wiązania disulfidowego. Opracowana metoda okazała się bardzo łagodna, wydajna, i niewrażliwa na obecność dodatkowych grup funkcyjnych.
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Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors
In the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as a novel inhibitors of steroid sulfatase (STS). The new compounds are potent STS inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect in the enzymatic...
Obtained scientific degrees/titles
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2018-09-19
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2018-05-09
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2010-02-12
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1996-06-11
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