The culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe the ability of four UAs—C-2028, C-2041, C-2045, and C-2053—to influence the growth of HCT116 and H460 spheres and the viability of HCT116...
Effects of unsymmetrical bisacridines on the spherical culture system of HCT116 colon and H460 lung cancer cell lines.
3D-spheroid cultures are receiving increasing attention in cancer research, as they serve as a link between simplified 2D monolayer culture structure and the highly complex nature of tumors in vivo. Therefore, spherical cultures are a good model for the effective testing of anticancer drugs. Unsymmetrical bisacridines (UAs) are new antitumor compounds, patented in Europe and in the USA. Here, two cancer cell lines: colon HCT116...
New antitumor unsymmetrical bisacridines derivatives affect c-myc and K-Ras level leading to cell death and accelerated senescence in human lung and colon cancer cells
Unsymmetrical bisacridines (UAs) are new antitumor derivatives patented in Europe (EP 3070078 B1) and USA (US 10202349 B2). In their structure they consist previously synthesized in our Department drugs: C-1311 and C-1748. Importantly, UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA, but interacts with quadruplex DNA. G-quadruplex structures are present in promoter regions of oncogenes,...
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