mgr inż. Krzysztof Pastuszak
Employment
- Assistant at Department of Algorithms and Systems Modelling
Social media
Contact
- krzpastu@pg.edu.pl
Assistant
- Department of Algorithms and Systems Modelling
- Faculty of Electronics, Telecommunications and Informatics
- Workplace
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Budynek A Elektroniki
room EA 226 open in new tab - Phone
- (58) 347 13 54
Publication showcase
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imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
Liquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we developed the imPlatelet classifier, which converts RNA-sequenced platelet data into images in which each pixel corresponds to the expression level of a certain gene. Biological knowledge from the Kyoto Encyclopedia...
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Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
The anticancer activity of bortezomib (BTZ) has been increasingly studied in a number of indications and promising results for the use of this treatment have been shown in neuroblastoma. As BTZ treatment is usually administered in cycles, the development of resistance and side effects in patients undergoing therapy with BTZ remains a major challenge for the clinical usage of this compound. Common resistance development also means...
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Transcriptomic landscape of blood platelets in healthy donors
Blood platelet RNA-sequencing is increasingly used among the scientific community. Aberrant platelet transcriptome is common in cancer or cardiovascular disease, but reference data on platelet RNA content in healthy individuals are scarce and merit complex investigation. We sought to explore the dynamics of platelet transcriptome. Datasets from 204 healthy donors were used for the analysis of splice variants, particularly with...
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