Year 2024

• CHEMOTHERAPY-MEDIATED COMPLICATIONS OF WOUND HEALING. AN UNDERSTUDIED SIDE EFFECT

  Publication

  • P. Słonimska
  • P. Sachadyn
  • J. Zieliński
  • M. Skrzypski
  • M. Pikuła

  - Advances in Wound Care - Year 2024

  Significance: Chemotherapy is a primary method to treat cancer, but while cytotoxic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types, including dermal cells and macrophages involved in wound healing, which often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent advances: Despite its...

  Full text available to download

Year 2020

• Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds

  Publication

  • M. Deptuła
  • P. Karpowicz
  • A. Wardowska
  • P. Sass
  • P. Sosnowski
  • A. Mieczkowska
  • N. Filipowicz
  • M. Dzierżyńska
  • J. Sawicka
  • E. Nowicka... and 14 others

  - Advances in Wound Care - Year 2020

  Objective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...

  Full text to download in external service