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Ministry points: Help
| Year | Points | List |
|---|---|---|
| Year 2022 | 70 | Ministry Scored Journals List 2019 |
| Year | Points | List |
|---|---|---|
| 2022 | 70 | Ministry Scored Journals List 2019 |
| 2021 | 70 | Ministry Scored Journals List 2019 |
| 2020 | 70 | Ministry Scored Journals List 2019 |
| 2019 | 70 | Ministry Scored Journals List 2019 |
| 2018 | 20 | A |
| 2017 | 20 | A |
| 2016 | 20 | A |
| 2015 | 15 | A |
Model:
Points CiteScore:
| Year | Points |
|---|---|
| Year 2021 | 3.9 |
| Year | Points |
|---|---|
| 2021 | 3.9 |
| 2020 | 3.4 |
| 2019 | 3 |
| 2018 | 2.8 |
| 2017 | 3.5 |
| 2016 | 3.4 |
| 2015 | 2.5 |
| 2014 | 1.3 |
| 2013 | 0.5 |
| 2012 | 0.1 |
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Papers published in journal
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total: 6
Catalog Journals
Year 2022
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3D spheroid culture system of HCT116 colon and A549 lung cancer cells in the study of the cellular response induced by antitumor unsymmetrical bisacridines in these cells.
Publication3D spheroid culture is a promising tool in cancer research, especially in drug development and testing. Here, the effects of antitumor unsymmetrical bisacridines (UAs) on 3D spheroids of HCT116 colon and A549 lung cancer cells were studied. The influence of four UAs: C-2028, C-2041, C-2045 and C-2053 on the morphology, size and viability of A549 cells was tested and compared with the results obtained for HCT116 cells [Kulesza J....
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Folic acid-unsymmetrical bisacridine conjugated quantum dots for improving tumor-targeted drug delivery
PublicationTargeted delivery of drugs to the tumor cells by nanoparticles (NPs) can increase the efficiency of cancer treatment. Chemotherapeutics can be delivered with NPs targeting surface proteins, overexpressed on the membrane of cancer cells. One of them is the folic acid receptors, which have a high affinity for folic acid (FA). C–2028 is the agent of patented [EP 3070078 B1 and US 10,202,349, B2], active antitumor drugs – unsymmetrical...
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Repression of L-methionine dependent fungal growth by L-penicillamine
PublicationInvasive fungal mycoses are a serious threat to human health, especially to immunosuppressed patients. A significant role of fungal infections in the death toll of COVID19 is also reported. Current antifungal therapies do not appear to be sufficient, therefore, identification of novel molecular targets is highly desirable. Enzymes participating in the biosynthesis pathways of essential amino acids like L-methionine (L-Met) seem...
Year 2021
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Effects of unsymmetrical bisacridines on the spherical culture system of HCT116 colon and H460 lung cancer cell lines.
Publication3D-spheroid cultures are receiving increasing attention in cancer research, as they serve as a link between simplified 2D monolayer culture structure and the highly complex nature of tumors in vivo. Therefore, spherical cultures are a good model for the effective testing of anticancer drugs. Unsymmetrical bisacridines (UAs) are new antitumor compounds, patented in Europe and in the USA. Here, two cancer cell lines: colon HCT116...
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New antitumor unsymmetrical bisacridines derivatives affect c-myc and K-Ras level leading to cell death and accelerated senescence in human lung and colon cancer cells
PublicationUnsymmetrical bisacridines (UAs) are new antitumor derivatives patented in Europe (EP 3070078 B1) and USA (US 10202349 B2). In their structure they consist previously synthesized in our Department drugs: C-1311 and C-1748. Importantly, UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA, but interacts with quadruplex DNA. G-quadruplex structures are present in promoter regions of oncogenes,...
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The conjugation of antitumor unsymmetrical bisacridines with quantum dots enhance cytotoxicity and change the biological response in lung and colon cancer cells
PublicationQuantum dots (QDs) are a novel class of semiconducting nanomaterials with unique properties, including drug delivery systems and biomedical applications. Unsymmetrical bisacridines (UAs), synthesized in our laboratory, patented in Europe [EP 3070078B1] and USA [US 10202349 B2], are a new class of antitumor agents highly active against many experimental cellular and tumor models, including lung, colon, pancreatic and prostate. Here,...
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