dr inż. Monika Pawłowska
Employment
- Assistant professor at Department of Pharmaceutical Technology and Biochemistry
- 2018 - present Postdoctoral research assistant at Department of Pharmaceutical Technology and Bichemistry
Social media
Contact
- monika.pawlowska@pg.edu.pl
Assistant professor
- Workplace
- Budynek B Wydziału Chemicznego pokój 117
- Phone
- (58) 347 12 97
Publication showcase
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The role of glucuronidation in drug resistance
The final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the anti-tumour imidazoacridinone C-1311 in human hepatoma cells
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The Influence of Antitumor Unsymmetrical Bisacridines on 3D Cancer Spheroids Growth and Viability
The culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe the ability of four UAs—C-2028, C-2041, C-2045, and C-2053—to influence the growth of HCT116 and H460 spheres and the viability of HCT116...
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