Description
This is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
The detailed information about the patient, sample, and diagnosis are as follows:
Patient:
Age: 50
Clinical description: The material was taken from the region of the left anterior superior iliac spine. The patient is undergoing a diagnosis of the lymphoproliferative process. Immunophenotyping of blood and marrow suggests marginal zone lymphoma.
Gender: Male
Diagnosis:Classification: ICD-O_3.2
Classification code: MALIGNANT LYMPHOMAS NOS OR DIFFUSE
Diagnosis: B-cell lymphoma, NOS
Result of the histopathological examination: Trepanobioptate in two fragments of a total length of 23 mm. Cellularity is approximately 90%. The bone marrow shows infiltrates of medium to large B lymphocytes with phenotype: CD45(+), CD20(+), Bcl2(+), CD43(+/-), MUM1(+), c-myc(+/-, in about 30% of cells). Reactions with CD10, Bcl6, CD5, Cyclin D1, SOX11, Annexin A1, DBA44, Tdt, CD34, CD23 and MPO are negative. MIB1/Ki67 60%. The infiltrates described above represent about 80% of all cells. In residually preserved normal hematopoietic tissue, E: M ratio =1:2. Granulocytic lineage (MPO+) with rejuvenation. Blastic cells with CD34 expression represent approximately 1% of all cells. Red cell lineage (CD71+) depleted. Quite numerous megakaryocytes (CD61+). Focal reticulin fibers (MF-1). The microscopic picture supports the diagnosis of B-cell lymphoma of high malignancy. Together with the phenotype determined cytometrically and the clinical presentation (splenomegaly), this is most likely a progression/transformation of splenic lymphoma (SMZL).
Sample:Material: FFPE
Collecting method: Bone marrow aspiration
Topography: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS
Organ: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS
Tissue: Bone marrow
Type of staining: positive/IHC
Staining: Not applicable
Antibody: Ki-67
Technology:Equipment: Pannoramic 250 3DHistech
Lens: 20x
Organization:Source: Medical University Gdańsk
Dataset file
hexmd5(md5(part1)+md5(part2)+...)-{parts_count}
where a single part of the file is 512 MB in size.Example script for calculation:
https://github.com/antespi/s3md5
File details
- License:
-
open in new tabCC BY-NC-SANon-commercial - Share-alike
- Raw data:
- Data contained in dataset was not processed.
- Software:
- CaseViewer 2.3
Details
- Year of publication:
- 2022
- Verification date:
- 2021-06-16
- Creation date:
- 2021
- Dataset language:
- English
- Fields of science:
-
- medical sciences (Medical and Health Sciences )
- DOI:
- DOI ID 10.34808/52ke-4n52 open in new tab
- Ethical papers:
- NKBBN/421-306/2020
- Verified by:
- Medical University of Gdańsk
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