B-cell lymphoma, NOS - Male, 50 - Cell image [3300730069484811] - Open Research Data - Bridge of Knowledge

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B-cell lymphoma, NOS - Male, 50 - Cell image [3300730069484811]

Description

This is the histopathological image of HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

The detailed information about the patient, sample, and diagnosis are as follows:

Patient:

Age: 50

Clinical description: The material was taken from the region of the left anterior superior iliac spine. The patient is undergoing a diagnosis of the lymphoproliferative process. Immunophenotyping of blood and marrow suggests marginal zone lymphoma.

Gender: Male

Diagnosis:

Classification: ICD-O_3.2

Classification code: MALIGNANT LYMPHOMAS NOS OR DIFFUSE

Diagnosis: B-cell lymphoma, NOS

Result of the histopathological examination: Trepanobioptate in two fragments of a total length of 23 mm. Cellularity is approximately 90%. The bone marrow shows infiltrates of medium to large B lymphocytes with phenotype: CD45(+), CD20(+), Bcl2(+), CD43(+/-), MUM1(+), c-myc(+/-, in about 30% of cells). Reactions with CD10, Bcl6, CD5, Cyclin D1, SOX11, Annexin A1, DBA44, Tdt, CD34, CD23 and MPO are negative. MIB1/Ki67 60%. The infiltrates described above represent about 80% of all cells. In residually preserved normal hematopoietic tissue, E: M ratio =1:2. Granulocytic lineage (MPO+) with rejuvenation. Blastic cells with CD34 expression represent approximately 1% of all cells. Red cell lineage (CD71+) depleted. Quite numerous megakaryocytes (CD61+). Focal reticulin fibers (MF-1). The microscopic picture supports the diagnosis of B-cell lymphoma of high malignancy. Together with the phenotype determined cytometrically and the clinical presentation (splenomegaly), this is most likely a progression/transformation of splenic lymphoma (SMZL).

Sample:

Material: FFPE

Collecting method: Bone marrow aspiration

Topography: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS

Organ: HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS

Tissue: Bone marrow

Type of staining: positive/IHC

Staining: Not applicable

Antibody: Annexin A1

Technology:

Equipment: Pannoramic 250 3DHistech

Lens: 20x

Organization:

Source: Medical University Gdańsk

Dataset file

904256cf-92e6-4949-be3f-b98efe94d024
226.3 MB, S3 ETag , downloads: 23
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File details

License:
Creative Commons: by-nc-sa 4.0 open in new tab
CC BY-NC-SA
Non-commercial - Share-alike
Raw data:
Data contained in dataset was not processed.
Software:
CaseViewer 2.3

Details

Year of publication:
2022
Verification date:
2021-06-16
Creation date:
2021
Dataset language:
English
Fields of science:
  • medical sciences (Medical and Health Sciences )
DOI:
DOI ID 10.34808/bfpd-6c13 open in new tab
Ethical papers:
NKBBN/421-306/2020
Verified by:
Medical University of Gdańsk

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