Paweł Sachadyn - Science profile - MOST Wiedzy


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Budynek B Wydz. Chemii
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(58) 347 16 05

Publication showcase

  • Retained features of embryonic metabolism in the adult MRL mouse

    • R. Naviaux
    • T. Le
    • K. Bedelbaeva
    • J. Leferovich
    • D. Gourevitch
    • P. Sachadyn
    • X. Zhang
    • C. Lise
    • H. Ellen


    The MRL mouse is an inbred laboratory strain that was derived by selective breeding in 1960 from the rapidly growing LG/J (Large) strain. MRL mice grow to nearly twice the size of other commonly used mouse strains, display uncommonly robust healing and regeneration properties, and express later onset autoimmune traits similar to Systemic Lupus Erythematosis. The regeneration trait (heal) in the MRL mouse maps to 14-20 quantitative...

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  • Conservation and diversity of MutS proteins

    The homologues of MutS, mismatch repair protein, exist in all prokaryotes, with the exception of Actinobacteria, Mollicutes and part of the Archaea. Multiple alignments of 316 MutS amino acid sequences from 169 species revealed conserved residues and sequence motifs distinguishing MutS homologues. All MutS homologues show high conservation within the ATPase domain. MutS1, the homologue responsible for DNA mismatch recognition,...

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  • Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse

    • P. Sachadyn
    • X. Zhang
    • L. Clark
    • R. Naviaux
    • E. Heber-Katz

    - MITOCHONDRION - 2008

    The MRL/MpJ mouse is an inbred laboratory strain of Mus musculus, known to exhibit enhanced autoimmunity, increased wound healing, and increased regeneration properties. We report the full-length mitochondrial DNA (mtDNA) sequence of the MRL mouse (Accession # EU450583), and characterize the discovery of two naturally occurring heteroplasmic sites. The first is a T3900C substitution in the TpsiCloop of the tRNA methionine gene...

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Obtained scientific degrees/titles

  • 2016-11-01

    Obtained science title

    prof. nadzw. PG Biotechology (Chemical sciences)
  • 2010-11-22

    Obtained science degree

    dr hab. inż. Biotechnology (Biological sciences)

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