Piotr Kawczak - Publications - Bridge of Knowledge

Piotr Kawczak

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Year 2019

Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation
Publication
- K. Greber
- J. Zielińska
- Ł. Nierzwicki
- K. Ciura
- P. Kawczak
- J. Nowakowska
- T. Bączek
- W. Sawicki
- BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES - Year 2019
Short cationic lipopeptides are amphiphilic molecules that exhibit antimicrobial activity mainly against Grampositives. These compounds bind to bacterial membranes and disrupt their integrity. Here we examine the structure-activity relation (SAR) of lysine-based lipopeptides, with a prospect to rationally design more active compounds. The presented study aims to explain how antimicrobial activity of lipopeptides is affected by...

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