Biotechnological and pharmacological potential of bee products microbiota.

The main goal of the project is isolation from bee products bacterial strains that exhibit ability to production of antimicrobial compounds, biopolymers and enzymes of particular industrial importance. Important parts of the project will be optimizing growth conditions of producing strains and development of methods of purification of metabolites of interest. Whole genome sequencing will be performed for identification of genes that are responsible for production of these substances. In cooperation with the research group from University of Wrocław attempts will be made to identify the metabolites that exhibit antimicrobial activity and to determine their chemical structures.

Details

Financial Program Name:

OPUS

Organization:

Narodowe Centrum Nauki (NCN) (National Science Centre)

Agreement:

UMO-2021/41/B/NZ9/03929 z dnia 2022-08-01

Realisation period:

2021-11-26 - 2025-11-25

Project manager:

dr hab. inż. Piotr Szweda

Realised in:

Department of Pharmaceutical Technology and Biochemistry

External institutions participating in project:

Uniwersytet Wrocławski (Poland)

Request type:

National Research Programmes

Domestic:

Domestic project

Verified by:

Gdańsk University of Technology

Papers associated with that project

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total: 3

Year 2024

In Silico Safety Assessment of Bacillus Isolated from Polish Bee Pollen and Bee Bread as Novel Probiotic Candidates
Publication
- A. Hafeez
- K. Matejczuk (formerly: K. Pełka)
- R. Worobo
- P. Szweda
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2024
Bacillus species isolated from Polish bee pollen (BP) and bee bread (BB) were characterized for in silico probiotic and safety attributes. A probiogenomics approach was used, and in-depth genomic analysis was performed using a wide array of bioinformatics tools to investigate the presence of virulence and antibiotic resistance properties, mobile genetic elements, and secondary metabolites. Functional annotation and Carbohydrate-Active...

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Year 2023

Probiotic potential of Bacillus Isolates from Polish Bee Pollen and Bee Bread
Publication
- K. Matejczuk (formerly: K. Pełka)
- A. Hafeez
- R. Worobo
- P. Szweda
- Probiotics and Antimicrobial Proteins - Year 2023
The main goal of this study was the evaluation of the probiotic potential of 10 Bacillus spp. strains isolated from 5 bee bread and 3 bee pollen samples. The antagonistic interaction with Staphylococcus aureus and Escherichia coli was a primary criterion for the preliminary selection of the isolates. Three out of ten strains—PY2.3 (isolated from pollen), BP20.15 and BB10.1 (both isolated from bee bread)—were found to be possible...

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Whole-genome sequencing and antimicrobial potential of bacteria isolated from Polish honey
Publication
- A. Hafeez
- K. Matejczuk (formerly: K. Pełka)
- K. Buzun
- R. Worobo
- P. Szweda
- APPLIED MICROBIOLOGY AND BIOTECHNOLOGY - Year 2023
The aim of this study was the whole-genome analysis and assessment of the antimicrobial potential of bacterial isolates from honey harvested in one geographical location—the north of Poland. In total, 132 strains were derived from three honey samples, and the antimicrobial activity of CFAM (cell-free after-culture medium) was used as a criterion for strain selection and detailed genomic investigation. Two of the tested isolates...

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