Molecular logic lab-on-a-vesicle for intracellular diagnostics - Project - MOST Wiedzy

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Molecular logic lab-on-a-vesicle for intracellular diagnostics

A dysfunction of cells lining the inner walls of blood vessels, i.e. the endothelium, is the primary cause of many lifestyle related diseases. According to the WHO, those diseases accounted for 60% of all deaths worldwide in 2005. Tailor-made diagnostic tools for early and reliable identification of endothelial dysfunction are urgently needed both in fundamental research and clinical routine, respectively. The Marie Skłodowska-Curie action LOGIC LAB objects to develop and characterize innovative molecular logic gates that can be applied as advanced diagnostic tools for parallel analyte sensing in live mammalian cells. Thereby, providing a unique method to discover endothelial dysfunction and the onset of diseases much easier and earlier than so far. LOGIC LAB creates a multi-faceted and multi-sectoral research environment for the next generation of scientists in order to establish a novel type of molecular logic sensors that reliably operate in biological media – a crucial requirement for their application i.e. as rapid and easy-to-handle tools for intracellular diagnostics. With excellent cross-disciplinary scientific and complementary training provided in the network, we aim to educate highlyskilled young scientists in the fields of chemistry, physics and biology, who will significantly strengthen the international research community in the domain of molecular logic sensing. Thus, in the long term, LOGIC LAB aims to finally bridge the gap between lab bench and biological or medical practice. It is this gap, that so far prevents a wide-ranging use of existing molecular logic gates e.g. for the diagnosis of lifestyle-associated diseases.

Details

Project's acronym:
LOGIC LAB
Project's funding:
HORYZONT 2020
Agreement:
z dnia 2018-08-23
Realisation period:
2018-11-01 - 2022-10-31
Project manager:
dr hab. Julien Guthmuller
Team members:
Realised in:
Department of Theoretical Physics and Quantum Information
External institutions
participating in project:
  • SLOVAK ACADEMY OF SCIENCES (Slovakia)
  • UNIVERSITEIT LEIDEN (Netherlands)
  • DUBLIN CITY UNIVERSITY (Ireland)
  • FRIEDRICH-SCHILLER-UNIVERSITAT JENA (Germany)
  • UNIWERSYTET JAGIELLONSKI (Poland)
  • LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. (Germany)
  • SciClus GmbH & Co. KG (Germany)
  • MIMETAS BV (Netherlands)
Project's value:
3 538 684.00 EUR
Request type:
Międzynarodowy Program Badawczy
Domestic:
International project
Verification:
Gdańsk University of Technology

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