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Currently, one thousand million people suffer from neurological issues, such as epilepsy, Alzheimer’s and Parkinson’s diseases, migraines, sclerosis, or neural infections. In most cases, restoration of the neural path can be done by the introduction of electrodes within the neural tissue. Nowadays, the market of neural electrodes is mainly based on pure metals such as gold or platinum. The metals reveal plane rigid structure, which integrates poorly with the tissue environment. This, in turn, leads to degeneration of signal transmission and the effective lifetime of the electrode becomes limited. Modulation of the interfacing electrode by nanostructured material such as conducting polymer coating has recently become an attractive option for providing efficient signal transmission for neural application.
Because of this, the main aim of the proposal is to develop a multifunctional PEDOT-based electrode for neural tissue interface. The studies will include the fabrication and investigation of PEDOT-based electrode toward its electronic and chemical neural interface. The effect of three main conditions will be examined during the fabrication process: type of the polymer synthesis (electrodeposition, drop-casting), a form of the synthesized polymer coating (solid film, hydrogel), and type of the electrode substrate (rigid, flexible). The chemical interface of the specified PEDOT electrodes will be modified by the introduction of an antiinflammatory drug reservoir. The drug release profile of each electrode during the electrode stimulation will
be examined. The stability profile of PEDOT electrodes during its stimulation will be investigated. The stability mechanism will be proposed and discussed. Biological characterization of the electrodes will be evaluated in the presence of neural human cell lines. The project will allow for the performance of important research, the results of which will be gradually published in the peer-reviewed JCR journals. The results of the project will be presented at different international and national conferences. Moreover, the ongoing project will allow for the purchase of new equipment and laboratory accessories.
Details
- Financial Program Name:
- SONATA
- Organization:
- Narodowe Centrum Nauki (NCN) (National Science Centre)
- Agreement:
- UMO-2021/43/D/ST7/01362 z dnia 2022-09-01
- Realisation period:
- 2022-09-01 - 2025-08-31
- Project manager:
- dr inż. Karolina Cysewska
- Team members:
-
- Postdoc dr Mohammad Taghi Tourchi Moghadam
- Student scholarship Natalia Zalewska
- Student scholarship Matthias Nawrocki
- Realised in:
- Laboratorium Materiałów Funkcjonalnych ETI
- Project's value:
- 1 509 506.00 PLN
- Request type:
- National Research Programmes
- Domestic:
- Domestic project
- Verified by:
- Gdańsk University of Technology
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