DNA topoisomerase inhibitors with acridine and acridone scaffold as a novel antifungal agents - Project - MOST Wiedzy

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DNA topoisomerase inhibitors with acridine and acridone scaffold as a novel antifungal agents

Mycoses are a serious threat, not only to human life but also to food biosecurity, ecosystem, biodiversity and international markets. Current methods of preventing fungal infections remain unsatisfactory. With this in mind, the aim of my research project is to identify antifungal compounds out of  24 new acridine and acridone derivatives targeting fungal DNA topoisomerase. Based on my own results of preliminary studies as well as previously published scientific reports we propose a set of structures. We will check the antifungal activity of this compounds, the ability to affect virulence factors, cytotoxic activity against human cell lines and we will determined their molecular mechanism (the ability to penetrate into the cell, efflux pump affinity, the degree of intercalation to DNA, the mechanism of topoisomerase inhibition).

Details

Project's acronym:
ARGENTUM
Financial Program Name:
INNY
Organization:
Ministerstwo Nauki i Szkolnictwa Wyższego (MNiSW)
Agreement:
DEC-24/2020/IDUB/I.3.3 z dnia 2020-11-17
Realisation period:
2021-04-01 - 2023-03-31
Project manager:
dr inż. Kamila Rząd
Team members:
  • conceptualization, project administration dr hab. inż. Iwona Gabriel
  • investigation, methodology dr inż. Katarzyna Kozłowska-Tylingo
  • investigation, methodology dr inż. Ewa Paluszkiewicz
  • investigation, methodology dr inż. Damian Neubauer
  • investigation, methodology mgr inż. Mateusz Olszewski
  • project administration prof. dr hab. n. farm. Wojciech Kamysz
Realised in:
Department of Pharmaceutical Technology and Biochemistry
External institutions
participating in project:
  • Gdański Uniwersytet Medyczny (Poland)
Project's value:
298 450.00 PLN
Request type:
Inny
Domestic:
Domestic project
Verified by:
No verification

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