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The incidence of fungal infections caused by Candida spp. has increased dramatically during the past few decades, mainly due to the rise in the number of immunocompromised patients. Nowadays it is estimated that nearly a billion people have skin, nail and hair fungal infections, many 10s of millions mucosal candidiasis and more than 150 million people have serious fungal diseases, which have a major impact on their lives or are fatal. Development of effective and safe therapeutic treatment of fungal infections remains one of the major challenges for modern medicine. Resistance, toxicity and problems with the administration are the most important limitations of therapies carried out with conventional chemotherapeutics (azoles, polyenes or echinocandins). Thus, there is an urgent need to look for other active and safe agents which could be used in the treatment of candidiasis. The results of our preliminary investigations revealed the high antifungal potential of ethanolic extracts of propolis (EEPs) harvested in Polish apiaries. We also observed the importantly higher antimicrobial potential of propolis samples rich in flavonoids and synergistic effect of Polish propolis in combination with fluconazole and voriconazole. The aim of the research planned under the above project is: identication of the active ingredients of propolis, determination of their antifungal activity in vitro and in vivo (in mouse model systems), investigation of synergistic interactions with antifungal drugs and determination of the molecular mechanisms of antifungal activity of propolis components. Research will be conducted in cooperation with foreign partners: prof. Patrick Van Dijck from the Catholic University of Leuven and prof. David Williams of Cardiff University
Details
- Financial Program Name:
- OPUS
- Organization:
- Narodowe Centrum Nauki (NCN) (National Science Centre)
- Agreement:
- UMO-2020/39/B/NZ7/02901 z dnia 2021-07-20
- Realisation period:
- 2021-07-20 - 2026-04-19
- Project manager:
- dr hab. inż. Piotr Szweda
- Team members:
-
- PhD student Piotr Bollin
- PhD student Jeslin Cheruvathoor Jenny
- Wykonawca mgr inż. Justyna Walkusz
- wykonawca dr inż. Andrzej Stanisław Skwarecki
- PhD student mgr Mateusz Olszewski
- PhD student dr inż. Karolina Pełka
- Realised in:
- Department of Pharmaceutical Technology and Biochemistry
- External institutions
participating in project: -
- Uniwersytet Medyczny we Wrocławiu (Poland)
- Project's value:
- 1 998 800.00 PLN
- Request type:
- National Research Programmes
- Domestic:
- Domestic project
- Verified by:
- Gdańsk University of Technology
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