Radiosensitizing derivatives of pyrimidine or purine nucleobases: Mass spectrometry and quantum chemical studies on low-energy electron interactions in gas phase, water clusters and solutions - Project - MOST Wiedzy

Search

Radiosensitizing derivatives of pyrimidine or purine nucleobases: Mass spectrometry and quantum chemical studies on low-energy electron interactions in gas phase, water clusters and solutions

The results of the current studies will lead to the in-depth understanding of relation between the efficiency of DEA in the gas phase and the effectiveness of potential radiosensitizer under physiological environment. It is difficult to overestimate access to such knowledge in the context of new, capable radiosensitizers. The most thorough studied radiosensitizing MNuc, 5-bromo-2’-deoxyuriudine, has not been used in the clinic so far. One of the reason for that could be insufficient understanding of the processes responsible for radiosensitizing properties of MNucs. Explaining the details of DEA, the influence of water in particular, should allow for rational designing of radiosensitizers. The identification of resonances leading to DEA in the gas phase as well as optimization of activation barriers and thermodynamic stimuli of degradation channels open in water will hopefully result in super-radiosensitizers which ultimately could be employed in the clinic.

Details

Financial Program Name:
CEUS
Organization:
Narodowe Centrum Nauki (NCN) (National Science Centre)
Agreement:
UMO-2020/02/Y/ST4/00110 z dnia 2021-07-12
Realisation period:
2021-07-12 - 2025-07-11
Research team leader:
dr hab. inż. Sebastian Demkowicz
Realised in:
Department of Organic Chemistry
External institutions
participating in project:
  • Uniwersytet Gdański (Poland)
Project's value:
1 606 215.00 PLN
Request type:
International Research Programmes
Domestic:
International project
Verified by:
Gdańsk University of Technology

seen 25 times