Radiosensitizing derivatives of pyrimidine or purine nucleobases: Mass spectrometry and quantum chemical studies on low-energy electron interactions in gas phase, water clusters and solutions
Details
- Financial Program Name:
- CEUS
- Organization:
- Narodowe Centrum Nauki (NCN) (National Science Centre)
- Agreement:
- UMO-2020/02/Y/ST4/00110 z dnia 2021-07-12
- Realisation period:
- 2021-07-12 - 2025-07-11
- Research team leader:
- dr hab. inż. Sebastian Demkowicz
- Realised in:
- Department of Organic Chemistry
- External institutions
participating in project: -
- Uniwersytet Gdański (Poland)
- Project's value:
- 1 606 215.00 PLN
- Request type:
- International Research Programmes
- Domestic:
- International project
- Verified by:
- Gdańsk University of Technology
Papers associated with that project
Filters
total: 2
Catalog Projects
Year 2024
-
Surprising Radiolytic Stability of 8‑Thiomethyladenine in an Aqueous Solution
Publication8-Thiomethyladenine (ASCH3), a potentially radiosensitizing modified nucleobase, has been synthesized in a reaction between 8-thioadenine and methyl iodide. Despite favorable dissociative electron attachment (DEA) characteristics, the radiolysis of an aqueous solution of ASCH3 with a dose of X-ray amounting to as much as 300 Gy leads to no effects. Nevertheless, crossed electron-molecule beam experiments in the gas phase on ASCH3...
Year 2023
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Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment
PublicationWhen modified uridine derivatives are incorporated into DNA, radical species may form that cause DNA damage. This category of molecules has been proposed as radiosensitizers and is currently being researched. Here, we study electron attachment to 5-bromo-4-thiouracil (BrSU), a uracil derivative, and 5-bromo-4-thio-20 -deoxyuridine (BrSdU), with an attached deoxyribose moiety via the N-glycosidic (N1-C) bond. Quadrupole mass spectrometry...
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