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Abstract
This study sought to evaluate [99mTc(HYNIC-Galacto-RGD2)-(tricine)(TPPTS)] (99mTc-Galacto-RGD2: HYNIC = 6-hydrazinonicotinyl; Galacto-RGD2 = Glu[cyclo[Arg-Gly-Asp-D-Phe-Lys(SAA-PEG2-(1,2,3-triazole)-1-yl-4-ethylamide)]]2 (SAA = 7-amino-L-glycero-L-galacto-2,6-anhydro-7-eoxyheptanamide, and PEG2 = 3,6-dioxaoctanoic acid); and TPPTS = trisodium triphenylphosphine-3,3',3''-trisulfonate) as a new radiotracer for tumor imaging. Galacto-RGD2 was prepared via the copper(I)-catalyzed 1,3-dipolar azide−alkyne Huisgen cycloaddition. HYNICGalacto-RGD2 was prepared by reacting Galacto-RGD2 with sodium succinimidyl 6-(2-(2-sulfonatobenzaldehyde)hydrazono)nicotinate (HYNIC-OSu) in the presence of diisopropylethylamine, and was evaluated for its integrin αvβ3 binding affinity against 125I-echistatin bound to U87MG glioma cells.
Authors (9)
-
Shundong Ji
- Purdue University, West Lafayette School of Health Sciences
-
Andrzej Czerwiński
- Peptides International, Inc ..
-
Yang Zhou
- University, West Lafayette School of Health Sciences
-
Guoqiang Shao
- Purdue University School of Health Sciences
-
Francisco Valenzuela
- Peptides International, Inc ..
-
Satendra Chauhan
- Peptides International, Inc ..
-
Michael Pennington
- Peptides International, Inc ..
-
Shuang Liu
- Purdue University School of Health Sciences
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
MOLECULAR PHARMACEUTICS
no. 10,
edition 9,
pages 3304 - 3313,
ISSN: 1543-8384 - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Ji S., Czerwiński A., Zhou Y., Shao G., Valenzuela F., Sowiński P., Chauhan S., Pennington M., Liu S.: 99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging// MOLECULAR PHARMACEUTICS. -Vol. 10, iss. 9 (2013), s.3304-3313
- Verified by:
- Gdańsk University of Technology
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