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Abuse or contamination? Ratio determination of clenbuterol enantiomers to distinguish between doping use and meat contamination
Abstract
Clenbuterol has been detected in urine of several athletes during routine doping control in the past years. Athletes claimed that the clenbuterol was ingested by eating contaminated meat. Providing analytical prove for this claim is difficult. clenbuterol consists of two enantiomers, R(-) and S(+)-clenbuterol. Currently available human and veterinary preparations were found to consist of a racemic mixture of both enantiomers. When clenbuterol is administered to animals this ratio may change in meat and other edible products of the animal. It is hypothized that consumption of contaminated meat with an altered ratio will also change the ratio in the urine of the athlete. To prove this a controlled human trial was permformed in which subjects were administered clenbuterol by ingestion of drug preparations or by eating contaminated meat and liver. Urine samples of the subjects were collected and analyzed with chiral LC-MS/MS and SFC-MS/MS methods to measure the ratio of R(-)- and S(+)-clenbuterol.
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Authors (9)
-
Meijer Thijs
- RIKILT Wageningen University and Research Centre Wageningen, The Netherlands
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Maria K. Parr
- Freir Universitat Berlin, Institute of Pharmacy Berlin, Germany
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Marco Blokland
- RIKILT Wageningen University and Research Centre Wageningen, The Netherlands
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Franz Liebetrau
- RIKILT Wageningen University and Research Centre Wageningen, The Netherlands
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Alexander Schmidt
- Chromicent GmbH Berlin, Germany
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Mijo Stanic
- Chromicent GmbH Berlin, Germany
-
Dorota Kwiatkowska dr inż.
- Instytut Sportu - Państwowy Instytut Badawczy Zakład Badań Antydopingowych
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Saskia Sterk
- RIKILT Wageningen University and Research Centre Wageningen, The Netherlands
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Keywords
Details
- Category:
- Conference activity
- Type:
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Title of issue:
- Residues of Veterinary Drugs in Food : Proceedings of the RuroResidue VIII Conference. Conference on Resodues of Veterinary Drugs in Food strony 7333 - 7337
- Language:
- English
- Publication year:
- 2016
- Bibliographic description:
- Thijs M., Parr M., Blokland M., Liebetrau F., Schmidt A., Stanic M., Waraksa E., Kwiatkowska D., Sterk S.: Abuse or contamination? Ratio determination of clenbuterol enantiomers to distinguish between doping use and meat contamination// Residues of Veterinary Drugs in Food : Proceedings of the RuroResidue VIII Conference. Conference on Resodues of Veterinary Drugs in Food/ ed. Aldert A Bergwerff Egmond aan Zee, The Netherlands: Euro Residue VIII, 2016, s.7333-7337
- DOI:
- Digital Object Identifier (open in new tab) 10.18174/370325
- Verified by:
- Gdańsk University of Technology
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